INHIBITION OF HYDROXYAPATITE FORMATION BY ZIRCONOCENES

被引：29

作者：

KOUTSOPOULOS, S ^{[1
]}

DEMAKOPOULOS, J ^{[1
]}

ARGIRIOU, X ^{[1
]}

DALAS, E ^{[1
]}

KLOURAS, N ^{[1
]}

SPANOS, N ^{[1
]}

机构：

[1] UNIV PATRAS,DEPT CHEM,GR-26500 PATRAI,GREECE

来源：

LANGMUIR | 1995年 / 11卷 / 05期

关键词：

D O I：

10.1021/la00005a065

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effect of zirconocenes, used as drugs for various therapeutic applications, on the crystal growth of hydroxyapatite was investigated at sustained supersaturation. AU zirconocenes were found to inhibit crystal growth of hydroxyapatite possibily through adsorption onto the active sites for crystal growth. The kinetics results favored a Langmuir-type isotherm, suggesting a high affinity of zirconocene dichloride for hydroxyapatite.

引用

收藏

页码：1831 / 1834

页数：4

相关论文

共 30 条

[1] THE INFLUENCE OF POLYPHOSPHATES, PHOSPHONATES, AND POLY(CARBOXYLIC ACIDS) ON THE CRYSTAL-GROWTH OF HYDROXYAPATITE [J].

AMJAD, Z .

LANGMUIR, 1987, 3 (06) :1063-1069

[2] THE CRYSTALLIZATION OF HYDROXYAPATITE AND FLUORAPATITE IN THE PRESENCE OF MAGNESIUM-IONS [J].

AMJAD, Z ;

KOUTSOUKOS, PG ;

NANCOLLAS, GH .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1984, 101 (01) :250-256

[3]

BATES RG, 1973, DETERMINATION PH

[4]

BOSKEY AL, 1984, SCAN ELECTRON MICROS, V2, P943

[5] THE EFFECT OF GLUCOSE ON THE CRYSTALLIZATION OF HYDROXYAPATITE IN AQUEOUS-SOLUTIONS [J].

DALAS, E ;

KOUTSOUKOS, PG .

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS I, 1989, 85 :2465-2472

[6] INHIBITION OF HYDROXYAPATITE FORMATION BY TITANOCENES [J].

DALAS, E ;

KLOURAS, N ;

MANIATIS, C .

LANGMUIR, 1992, 8 (03) :1003-1006

[7] METALLOCENES IN BIOCHEMISTRY, MICROBIOLOGY AND MEDICINE [J].

DOMBROWSKI, KE ;

BALDWIN, W ;

SHEATS, JE .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1986, 302 (03) :281-306

[8] METALLOCENE HALIDES .I. SYNTHESIS, SPECTRA, AND REDISTRIBUTION EQUILIBRIA OF DI-PI-CYCLOPENTADIENYLDIHALOGENO-TITANIUM(4),-ZIRCONIUM-(4), AND -HAFNIUM(4) [J].

DRUCE, PM ;

KINGSTON, BM ;

LAPPERT, MF ;

SPALDING, TR ;

SRIVASTA, RC .

JOURNAL OF THE CHEMICAL SOCIETY A -INORGANIC PHYSICAL THEORETICAL, 1969, (14) :2106-+

[9] IRRITANCY AND ANTIINFLAMMATORY ACTIVITY OF BIS(ETA-5-CYCLOPENTADIENYL)TITANIUM(IV) COMPLEXES IN RATS [J].

FAIRLIE, DP ;

WHITEHOUSE, MW ;

BROOMHEAD, JA .

CHEMICO-BIOLOGICAL INTERACTIONS, 1987, 61 (03) :277-291

[10] SYNOVIAL-FLUID CRYSTALS IN OSTEO-ARTHRITIS [J].

GIBILISCO, PA ;

SCHUMACHER, HR ;

HOLLANDER, JL ;

SOPER, KA .

ARTHRITIS AND RHEUMATISM, 1985, 28 (05) :511-515