REGIONAL CEREBRAL BLOOD-FLOW OF ALZHEIMERS DISEASE-LIKE PATTERN IN YOUNG-PATIENTS WITH DOWNS-SYNDROME DETECTED BY TC-99(M)-HMPAO BRAIN SPECT

被引：21

作者：

KAO, CH

WANG, PY

WANG, SJ

CHOU, KT

HSU, CY

LIN, WY

LIAO, SQ

YEH, SH

机构：

[1] Departments of Nuclear Medicine and Neurology, Taichung Taiwan, 40705, 160 Taichung Harbor Road

[2] Taichung Veterans General Hospital, Taichung Taiwan, 40705, 160 Taichung Harbor Road

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1993年 / 14卷 / 01期

关键词：

D O I：

10.1097/00006231-199301000-00010

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Fourteen young patients with Down's syndrome (nine males, five females, age range 8-30 years) were studied. Tc-99m-hexamethylpropylene amine oxime (HMPAO) brain single photon emission computed tomography (SPECT) was performed to evaluate regional cerebral blood flow (rCBF). Two experienced nuclear medicine physicians analysed the results of the SPECT by visual interpretation. The SPECT in all 14 patients with Down's syndrome invariably showed significantly unilateral perfusion defects in the temporal-parietal-occipital region, occasionally combined with small perfusion defects over other discrete cerebral areas. In this preliminary study, Tc-99m-HMPAO brain SPECT in the patients with Down's syndrome were abnormal. Patterns of rCBF in Down's syndrome were similar to the usual images of rCBF in Alzheimer's disease reported in the literature. Our findings provide new evidence of the similarities between Down's syndrome and Alzheimer's disease.

引用

页码：47 / 51

页数：5

共 25 条

[21]

Nakayasu H., Araga S., Takahashi K., Otsuki K., Murata M., Two cases of adult Down's syndrome presenting parietal low uptake in 123I-IMP-SPECT, Rinsho Shinkeigaku (Clin Neurol), 31, pp. 557-560, (1991)

[22]

Pelizzari C.A., Chen G.T., Spelbring D.R., Weichselbam R.R., Chen C.T., Accurate three-dimensional registration of CT, PET, and/or MR images of the brain, J Comput Assist Tomogr, 13, pp. 20-26, (1989)

[23]

Brun A., Englund E., Regional pattern of degeneration in Alzheimer's disease: Neuronal loss and histopathological grading, Histopathology, 5, pp. 549-564, (1981)

[24]

Woods S.W., Pearsall H.R., Seibyl J.P., Hoffer P.B., The Quinn essay: Single-photon emission computed tomography in neuropsychiatric disorders, 1991 Year Book of Nuclear Medicine, pp. 13-57, (1991)

[25]

Sinex F.M., Kraus L.J., Altered purine biosynthesis and the pathogenesis of Alzheimer's disease: A hypothesis, Alzheimer's Disease and Related Disorders, pp. 105-117, (1984)

← 1 2 3 →