A 2.8 MB YAC CONTIG IN 11Q12-Q13 LOCALIZES CANDIDATE GENES FOR ATOPY - FC-EPSILON-RI-BETA AND CD20

被引：29

作者：

STAFFORD, AN

RIDER, SH

HOPKIN, JM

COOKSON, WO

MONACO, AP

机构：

[1] JOHN RADCLIFFE HOSP,NUFFIELD DEPT CLIN MED,OXFORD OX3 9DU,ENGLAND

[2] CHURCHILL HOSP,OSLER CHEST UNIT,OXFORD OX3 7LJ,ENGLAND

来源：

HUMAN MOLECULAR GENETICS | 1994年 / 3卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1093/hmg/3.5.779

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An important locus for Atopy (familial asthma, hay fever and eczema) has been localized to the 11q12 - q13 region with the minimum recombination fraction around the CD20 gene. We have constructed a 2.8 megabase (Mb) Yeast Artificial Chromosome (YAC) contig of the candidate region using 15 STSs. A total of seven genes have been mapped within this interval in the order cen-OSBP-TCN1-GIF-Fc epsilon RI beta-CD20-CD5-PGA-q(ter) and can be covered by a minimum of eight YAC clones. Contig integrity was assayed with fluorescence in-situ hybridization (FISH) and the mapping of YAC ends on somatic cell and radiation hybrid panels. A long range restriction map of the contig has been constructed to establish the order of and distance between loci. Two promising candidates for the atopy locus, the beta subunit of the high affinity immunoglobulin E receptor (Fc epsilon RI beta) and CD20, a molecule involved in B cell differentiation, have been placed within the contig.

引用

页码：779 / 785

页数：7

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