CDNA CLONING AND CHROMOSOMAL LOCALIZATION OF THE HUMAN BETA-ADRENERGIC-RECEPTOR KINASE

被引：37

作者：

BENOVIC, JL ^{[1
]}

STONE, WC ^{[1
]}

HUEBNER, K ^{[1
]}

CROCE, C ^{[1
]}

CARON, MG ^{[1
]}

LEFKOWITZ, RJ ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DURHAM,NC 27710

来源：

FEBS LETTERS | 1991年 / 283卷 / 01期

关键词：

BETA-ADRENERGIC RECEPTOR KINASE; HUMAN; CHROMOSOME; DESENSITIZATION; PHOSPHORYLATION; CDNA;

D O I：

10.1016/0014-5793(91)80568-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The beta-adrenergic receptor kinase (beta-ARK) mediates agonist-dependent phosphorylation of the beta-2-adrenergic and related G protein-coupled receptors. A cDNA encoding bovine beta-ARK has recently been isolated. In this work we have isolated a cDNA encoding human beta-ARK from a retinal cDNA library. The cDNA encodes a protein of 689 amino acids with an overall 98.0% amino acid and 92.5% nucleotide identity with bovine beta-ARK. Chromosomal location of the human beta-ARK gene was determined by correlating the presence of the beta-ARK locus with retention of a specific human chromosome in a rodent-human hybrid panel. This analysis revealed that the human beta-ARK locus segregated with the long arm of chromosome 11, centromeric to 11q13.

引用

页码：122 / 126

页数：5

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