CDNA CLONING AND CHROMOSOMAL LOCALIZATION OF THE HUMAN BETA-ADRENERGIC-RECEPTOR KINASE

被引：37

作者：

BENOVIC, JL ^{[1
]}

STONE, WC ^{[1
]}

HUEBNER, K ^{[1
]}

CROCE, C ^{[1
]}

CARON, MG ^{[1
]}

LEFKOWITZ, RJ ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DURHAM,NC 27710

来源：

FEBS LETTERS | 1991年 / 283卷 / 01期

关键词：

BETA-ADRENERGIC RECEPTOR KINASE; HUMAN; CHROMOSOME; DESENSITIZATION; PHOSPHORYLATION; CDNA;

D O I：

10.1016/0014-5793(91)80568-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The beta-adrenergic receptor kinase (beta-ARK) mediates agonist-dependent phosphorylation of the beta-2-adrenergic and related G protein-coupled receptors. A cDNA encoding bovine beta-ARK has recently been isolated. In this work we have isolated a cDNA encoding human beta-ARK from a retinal cDNA library. The cDNA encodes a protein of 689 amino acids with an overall 98.0% amino acid and 92.5% nucleotide identity with bovine beta-ARK. Chromosomal location of the human beta-ARK gene was determined by correlating the presence of the beta-ARK locus with retention of a specific human chromosome in a rodent-human hybrid panel. This analysis revealed that the human beta-ARK locus segregated with the long arm of chromosome 11, centromeric to 11q13.

引用

页码：122 / 126

页数：5

共 21 条

[11] TURNING OFF THE SIGNAL - DESENSITIZATION OF BETA-ADRENERGIC-RECEPTOR FUNCTION [J].

HAUSDORFF, WP ;

CARON, MG ;

LEFKOWITZ, RJ .

FASEB JOURNAL, 1990, 4 (11) :2881-2889

[12]

HUEBNER K, 1988, ONCOGENE RES, V3, P263

[13] DO THE POLY(A) TAIL AND 3' UNTRANSLATED REGION CONTROL MESSENGER-RNA TRANSLATION [J].

JACKSON, RJ ;

STANDART, N .

CELL, 1990, 62 (01) :15-24

[14] PHOSPHORYLATION OF CHICK HEART MUSCARINIC CHOLINERGIC RECEPTORS BY THE BETA-ADRENERGIC-RECEPTOR KINASE [J].

KWATRA, MM ;

BENOVIC, JL ;

CARON, MG ;

LEFKOWITZ, RJ ;

HOSEY, MM .

BIOCHEMISTRY, 1989, 28 (11) :4543-4547

[15]

LIDEREAU R, 1988, ONCOGENE RES, V2, P285

[16]

LOHSE MJ, 1990, J BIOL CHEM, V265, P3202

[17] INHIBITION OF BETA-ADRENERGIC-RECEPTOR KINASE PREVENTS RAPID HOMOLOGOUS DESENSITIZATION OF BETA-2-ADRENERGIC RECEPTORS [J].

LOHSE, MJ ;

LEFKOWITZ, RJ ;

CARON, MG ;

BENOVIC, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (09) :3011-3015

[18] DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS [J].

SANGER, F ;

NICKLEN, S ;

COULSON, AR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5463-5467

[19] DNA RESTRICTION ENDONUCLEASE ANALYSIS FOR LOCALIZATION OF HUMAN BETA-GLOBIN AND DELTA-GLOBIN GENES ON CHROMOSOME-11 [J].

SCOTT, AF ;

PHILLIPS, JA ;

MIGEON, BR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (09) :4563-4565

[20]

THEILLET C, 1990, ONCOGENE, V5, P147

← 1 2 3 →