MOLECULAR CONTROL OF RABBIT URINARY-BLADDER HYPERTROPHY

被引：8

作者：

BUTTYAN, R ^{[1
]}

CHEN, MW ^{[1
]}

MONSON, F ^{[1
]}

LEVIN, RM ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,VET ADM MED CTR,DIV UROL,PHILADELPHIA,PA 19104

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1994年 / 48卷

基金：

美国国家卫生研究院;

关键词：

URINARY BLADDER HYPERTROPHY; HYPERPLASIA; APOPTOSIS; GROWTH FACTORS;

D O I：

10.1016/S0753-3322(09)80006-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chronic obstruction of the lower genitourinary tract, the major manifestation of BPH, results in characteristic pathological changes in the structure and function of the bladder. Here, we describe how an experimental animal model of bladder outlet obstruction involving the rabbit has been used to identify specific genetic markers associated with the response of the bladder to partial outlet obstruction. More important, these types of studies indicate that two particular growth factors, basic fibroblast growth factor and transforming growth factor-beta, act in a strategic and opposing manner to regulate bladder growth and regression in response to partial outlet obstruction.

引用

页码：S27 / S34

页数：8

共 21 条

[1]

ARENDS MJ, 1990, AM J PATHOL, V136, P593

[2] EARLY MOLECULAR RESPONSE TO RABBIT BLADDER OUTLET OBSTRUCTION [J].

BUTTYAN, R ;

JACOBS, BZ ;

BLAIVAS, JG ;

LEVIN, RM .

NEUROUROLOGY AND URODYNAMICS, 1992, 11 (03) :225-238

[3] AN EARLY MOLECULAR RESPONSE INDUCED BY ACUTE OVERDISTENSION OF THE RABBIT URINARY-BLADDER [J].

CHEN, MW ;

KRASNAPOLSKY, L ;

LEVIN, RM ;

BUTTYAN, R .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 1994, 132 (01) :39-44

[4] EFFECT OF VESICAL OUTLET OBSTRUCTION ON DETRUSOR CONTRACTILITY AND PASSIVE PROPERTIES IN RABBITS [J].

GHONIEM, GM ;

REGNIER, CH ;

BIANCANI, P ;

JOHNSON, L ;

SUSSET, JG .

JOURNAL OF UROLOGY, 1986, 135 (06) :1284-1289

[5] THE FUNCTIONAL EFFECT OF MILD OUTLET OBSTRUCTION ON THE RABBIT URINARY-BLADDER [J].

KATO, K ;

WEIN, AJ ;

KITADA, S ;

HAUGAARD, N ;

LEVIN, RM .

JOURNAL OF UROLOGY, 1988, 140 (04) :880-884

[6] APOPTOSIS - BASIC BIOLOGICAL PHENOMENON WITH WIDE-RANGING IMPLICATIONS IN TISSUE KINETICS [J].

KERR, JFR ;

WYLLIE, AH ;

CURRIE, AR .

BRITISH JOURNAL OF CANCER, 1972, 26 (04) :239-+

[7] PURIFICATION AND COMPLEMENTARY-DNA CLONING OF A RECEPTOR FOR BASIC FIBROBLAST GROWTH-FACTOR [J].

LEE, PL ;

JOHNSON, DE ;

COUSENS, LS ;

FRIED, VA ;

WILLIAMS, LT .

SCIENCE, 1989, 245 (4913) :57-60

[8]

LEVIN R, 1989, Journal of Urology, V141, p335A

[9] TRYPAN BLUE AS AN INDICATOR OF UROTHELIAL INTEGRITY [J].

LEVIN, RM ;

WEIN, AJ ;

WHITMORE, K ;

MONSON, FC ;

MCKENNA, BAW ;

RUGGIERI, MR .

NEUROUROLOGY AND URODYNAMICS, 1990, 9 (03) :269-279

[10] RECOVERY FROM SHORT-TERM OBSTRUCTION OF THE RABBIT URINARY-BLADDER [J].

LEVIN, RM ;

MALKOWICZ, SB ;

WEIN, AJ ;

ATTA, MA ;

ELBADAWI, A .

JOURNAL OF UROLOGY, 1985, 134 (02) :388-390

← 1 2 3 →