MOLECULAR CONTROL OF RABBIT URINARY-BLADDER HYPERTROPHY

被引：8

作者：

BUTTYAN, R ^{[1
]}

CHEN, MW ^{[1
]}

MONSON, F ^{[1
]}

LEVIN, RM ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,VET ADM MED CTR,DIV UROL,PHILADELPHIA,PA 19104

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1994年 / 48卷

基金：

美国国家卫生研究院;

关键词：

URINARY BLADDER HYPERTROPHY; HYPERPLASIA; APOPTOSIS; GROWTH FACTORS;

D O I：

10.1016/S0753-3322(09)80006-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chronic obstruction of the lower genitourinary tract, the major manifestation of BPH, results in characteristic pathological changes in the structure and function of the bladder. Here, we describe how an experimental animal model of bladder outlet obstruction involving the rabbit has been used to identify specific genetic markers associated with the response of the bladder to partial outlet obstruction. More important, these types of studies indicate that two particular growth factors, basic fibroblast growth factor and transforming growth factor-beta, act in a strategic and opposing manner to regulate bladder growth and regression in response to partial outlet obstruction.

引用

页码：S27 / S34

页数：8

共 21 条

[11]

Levin Robert M., 1993, P119

[12] ACUTE BIOCHEMICAL AND FUNCTIONAL ALTERATIONS IN THE PARTIALLY OBSTRUCTED RABBIT URINARY-BLADDER [J].

MALKOWICZ, SB ;

WEIN, AJ ;

ELBADAWI, A ;

VANARSDALEN, K ;

RUGGIERI, MR ;

LEVIN, RM .

JOURNAL OF UROLOGY, 1986, 136 (06) :1324-1329

[13] CHANGES IN CONTRACTILE PROPERTIES IN HYPERTROPHIC RAT URINARY-BLADDER [J].

MATTIASSON, A ;

UVELIUS, B .

JOURNAL OF UROLOGY, 1982, 128 (06) :1340-1342

[14]

MESSING EM, 1990, CANCER RES, V50, P2530

[15] STIMULATION OF DNA-SYNTHESIS IN RABBIT BLADDER WALL AFTER PARTIAL OUTLET OBSTRUCTION AND ACUTE OVERDISTENSION [J].

MONSON, FC ;

WEIN, AJ ;

EIKA, B ;

MURPHY, M ;

LEVIN, RM .

NEUROUROLOGY AND URODYNAMICS, 1994, 13 (01) :51-61

[16]

MOSTWIN JL, 1989, J UROLOGY, pA141

[17] HUMAN EPIDERMAL GROWTH FACTOR-ON MOLECULAR-FORMS PRESENT IN URINE AND BLOOD [J].

NEXO, E ;

JORGENSEN, PE ;

HANSEN, MR .

REGULATORY PEPTIDES, 1992, 42 (1-2) :75-84

[18]

ROHNER T J JR, 1978, Urology, V11, P357, DOI 10.1016/0090-4295(78)90231-5

[19]

SANTAROSA R, 1994, LAB INVEST, V70, P503

[20] BLADDER OUTFLOW OBSTRUCTION - A CAUSE OF DENERVATION SUPERSENSITIVITY [J].

SPEAKMAN, MJ ;

BRADING, AF ;

GILPIN, CJ ;

DIXON, JS ;

GILPIN, SA ;

GOSLING, JA .

JOURNAL OF UROLOGY, 1987, 138 (06) :1461-1466

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