CRYSTAL-NEUTROPHIL INTERACTIONS LEAD TO INTERLEUKIN-1 SYNTHESIS

被引：50

作者：

ROBERGE, CJ

GRASSI, J

DEMEDICIS, R

FROBERT, Y

LUSSIER, A

NACCACHE, PH

POUBELLE, PE

机构：

[1] CHUS,UNITES MALAD RHUMATISMALES,SHERBROOKE,QUEBEC,CANADA

[2] CENS,SECT PHARMACOL & IMMUNOL,F-91191 GIF SUR YVETTE,FRANCE

[3] CHUL,CTR RECH,UNITE RECH INFLAMMAT & IMMUNOL RHUMATOL,2705 BLVD LAURIER,QUEBEC CITY G1V 4G2,QUEBEC,CANADA

来源：

AGENTS AND ACTIONS | 1991年 / 34卷 / 1-2期

关键词：

D O I：

10.1007/BF01993232

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Normal human blood neutrophils were studied for their capacity to synthesize and release interleukin-1 (IL-1) species after phagocytosis of triclinic monosodium urate (MSU) and calcium pyrophosphate dihydrate crystals (CPPD). MSU crystals were more potent inducers of IL-1 generation than CPPD or unopsonized zymosan. Microcrystal-stimulated neutrophils characteristically secreted most of the newly synthesized IL-1. Colchicine partly inhibited the secretion of IL-1 by neutrophils during phagocytosis of solid particles. However, colchicine selectively inhibited IL-1 synthesis induced by microcrystals. These results suggest that neutrophil-derived IL-1 may contribute to the pathogenesis of crystal-induced arthritis.

引用

页码：38 / 41

页数：4

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