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BIOCHEMICAL SCREENING-TEST FOR THE PHOTOSENSITIZING POTENTIAL OF DRUGS AND DISINFECTANTS

被引：19
作者：
SCHOTHORST, AA
SUURMOND, D
DELIJSTER, A
机构：
[1] Department of Dermatology, University Hospital, Leiden
来源：
PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1979年 / 29卷 / 03期
关键词：
D O I：
10.1111/j.1751-1097.1979.tb07086.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Abstract— A series of photosensitizers known to cause photodermatitis were tested with respect to photosensitizing properties. Irradiation of these sensitizers together with unsaturated fatty acids or amino acids showed that few of them can be transformed by most of the photosensitizers. SH groups can. however, be destroyed by most of the photosensitizers known in dermatological practice. At low photosensitizer‐to‐SH group ratios, GSSG is formed; at higher ratios, other transformations of GSH predominates. The reactivity of GSH with ninhydrin is decreased after irradiation with a photo‐sensitizer. Glutathione seems to be a biomolecule that is suitably sensitive to photosensitized modification and thus suitable for evaluation of any photosensitizing activity that new drugs may have as an unwanted side effect. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：531 / 537
页数：7
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