FREE-RADICALS AND ANTICANCER DRUG-RESISTANCE - OXYGEN FREE-RADICALS IN THE MECHANISMS OF DRUG CYTOTOXICITY AND RESISTANCE BY CERTAIN TUMORS

被引：177

作者：

SINHA, BK

MIMNAUGH, EG

机构：

[1] Medicine Branch, Clinical Oncology Program, National Cancer Institute, Bethesda

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 8卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Antioxidant enzymes; Glutathione peroxidase; Multi-drug resistance; Oxyradicals; Quinone-containing anticancer drugs; Resistance; Tumor cells;

D O I：

10.1016/0891-5849(90)90155-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Certain anticancer agents form free radical intermediates during enzymatic activation. Recent studies have indicated that free radicals generated from adriamycin and mitomycin C may play a critical role in their toxicity to human tumor cells. Furthermore, it is becoming increasingly apparent that reduced drug activation and or enhanced detoxification of reactive oxygen species may be related to the resistance to these anticancer agents by certain tumor cell lines. The purposes of this review are to summarize the evidence pointing toward the significance of free radicals formation in drug toxicity and to evaluate the role of decreased free radical formation and enhanced free radical scavenging and detoxification in the development of anticancer drug resistance by a spectrum of tumor cell types. Studies failing to support the participation of oxyradicals in the cytotoxicity and resistance of adriamycin are also discussed. © 1990.

引用

页码：567 / 581

页数：15

共 93 条

[1]

Juliano, Ling, A surface glycoprotein modulating drug permeabiality in Chinese hamster ovary cell mutants, Biochem. Biophys. Acta, 455, pp. 152-162, (1976)

[2]

Riordan, Deuchars, Kartner, Alon, Trent, Ling, Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines, Nature, 316, pp. 817-819, (1985)

[3]

Seeber, Osiela, Schmidt, Achterrrah, Crook, In vivo resistance towards anthracyclines, etoposide, and diamino-dicholroplatinum (I), Cancer Res., 42, pp. 4719-4725, (1982)

[4]

Pommier, Kerrigan, Kohn, Topoisomerase alternations associated with drug resistance in a line of Chinese hamster cells, NCI Monographs, 4, pp. 83-87, (1987)

[5]

Gottesman, Pastan, Resistance to multiple chemotherapeutic agents in human cancer cells, Trends Pharm. Sci., 9, pp. 54-58, (1988)

[6]

Bhalla, Hindenburg, Taub, Grant, Isolation and characterization of an anthracycline-resistant human leukemic cell line, Cancer Res., 45, pp. 3657-3662, (1985)

[7]

Harker, Sikic, Multidrug (pleiotropic) resistance in doxorubicin-selected variants of the human sarcoma cell line MES-SA, Cancer Res., 45, pp. 4091-4096, (1985)

[8]

Lai, Goldstein, Gottesman, Pastan, Tsai, Johnson, Mulshine, Ihde, Kayser, Gazdar, MDR1 gene expression in lung cancer, J. Natl. Cancer Inst., 81, pp. 1144-1150, (1989)

[9]

Harker, Slade, Dalton, Meltzer, Trent, Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-glycoprotein overexpression, Cancer Res., 49, pp. 4542-4549, (1989)

[10]

Haber, Norris, Kavallaris, Bell, Davey, White, Stewart, Atypical multidrug resistance in a therapy-induced drug-resistant human leukemia cell line (LALW-2): resistance to vinca alkaloids independent of P-glycoprotein, Cancer Res., 49, pp. 5281-5287, (1989)

← 1 2 3 4 5 6 7 8 9 10 →