FREE-RADICALS AND ANTICANCER DRUG-RESISTANCE - OXYGEN FREE-RADICALS IN THE MECHANISMS OF DRUG CYTOTOXICITY AND RESISTANCE BY CERTAIN TUMORS

被引：177

作者：

SINHA, BK

MIMNAUGH, EG

机构：

[1] Medicine Branch, Clinical Oncology Program, National Cancer Institute, Bethesda

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 8卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Antioxidant enzymes; Glutathione peroxidase; Multi-drug resistance; Oxyradicals; Quinone-containing anticancer drugs; Resistance; Tumor cells;

D O I：

10.1016/0891-5849(90)90155-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Certain anticancer agents form free radical intermediates during enzymatic activation. Recent studies have indicated that free radicals generated from adriamycin and mitomycin C may play a critical role in their toxicity to human tumor cells. Furthermore, it is becoming increasingly apparent that reduced drug activation and or enhanced detoxification of reactive oxygen species may be related to the resistance to these anticancer agents by certain tumor cell lines. The purposes of this review are to summarize the evidence pointing toward the significance of free radicals formation in drug toxicity and to evaluate the role of decreased free radical formation and enhanced free radical scavenging and detoxification in the development of anticancer drug resistance by a spectrum of tumor cell types. Studies failing to support the participation of oxyradicals in the cytotoxicity and resistance of adriamycin are also discussed. © 1990.

引用

页码：567 / 581

页数：15

共 93 条

[61]

Arrick, Nathan, Griffith, Meister, Glutathione depletion sensitizes tumor cells to oxidative cytolysis, J. Biol. Chem., 257, pp. 1231-1237, (1982)

[62]

Russo, Mitchell, Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation, Cancer Treat. Rep., 69, pp. 1293-1296, (1985)

[63]

Bozzi, Mavelli, Mondovi, Strom, Rotilio, Differential cytotoxicity of daunomycin in tumor cells is related to glutathione-dependent hydrogen peroxide metabolism, Biochem. J., 194, pp. 369-372, (1981)

[64]

Kramer, Zakher, Kim, Role of glutathione redox cycle in acquired and de novo multidrug resistance, Science, 241, pp. 694-697, (1988)

[65]

Safa, Photoaffinity labeling of the multidrug resistance-related P-glycoprotein with photoactive analogs of verapaminl, Proc. Natl. Acad. Sci (USA), 85, pp. 7187-7191, (1988)

[66]

Meijer, Mulder, Timmer-Bosscha, Zijlstra, de Vries, Role of free radicals in an adriamycin-resistant human small cell lung cancer cell line, Cancer Res., 47, pp. 4613-4617, (1987)

[67]

de Vries, Meijer, Timmer-Bosscha, Berendsen, de Leiji, Schper, Mulder, Resistance mechanism in three human small cell lung cell lines established from one patient during clinical follow up, Cancer Res., 49, pp. 4175-4178, (1989)

[68]

Bredehorst, Panneerselvam, Vogel, Doxurubicin enhances complement susceptibility of human melanoma cells by extracellular oxygen radical formation, J. Biol. Chem., 262, pp. 2034-2041, (1987)

[69]

Keizer, van Rijin, Pinedo, Joenje, Effects of endogenous glutathione, superoxide dismutase, catalase, and glutathione peroxidase on adriamycin tolelarnce of Chinese hamster ovary cells, Cancer Res., 48, pp. 4493-4497, (1988)

[70]

Bellamy, Dalton, Meltzer, Dorr, Role of glutathione and its associated enzymes in multidrug-resistant human myeloma cells, Biochem. Pharmacol., 38, pp. 787-793, (1989)

← 1 2 3 4 5 6 7 8 9 10 →