ACETOGENINS OF THE ANNONACEAE .20. BIOACTIVE ACETOGENINS FROM SEEDS OF ANNONA-CHERIMOLIA

被引：48

作者：

CORTES, D

MYINT, SH

DUPONT, B

DAVOUST, D

机构：

[1] UNIV ROUEN, CHIM ORGAN LAB, SERV RMN, CNRS, URA 464, F-76134 MONT ST AIGNAN, FRANCE

[2] UNIV PARIS 11, FAC PHARM, CNRS, PHARMACOGNOSIE LAB, F-92290 CHATENAY MALABRY, FRANCE

来源：

PHYTOCHEMISTRY | 1993年 / 32卷 / 06期

关键词：

ANNONA-CHERIMOLIA; ANNONACEAE; ACETOGENINS; TETRAHYDROFURAN GAMMA-LACTONES; CYTOTOXICITY; ANTIPARASITIC ACTIVITY;

D O I：

10.1016/0031-9422(93)85162-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new cytotoxic, nonadjacent bis-tetrahydrofuran acetogenins, cherimolin-2 and almunequin, have been isolated from the bioactive methanolic extract of Annona cherimolia seeds. In addition to these new compounds, the structure of the known acetogenins, cherimolin-1, laherradurin and otivarin (ex-dihydrocherimolin), are here revised. The structures were established by means of one- and two-dimensional NMR experiments. All compounds exhibited potent cytotoxic and antiparasitic activities.

引用

页码：1475 / 1482

页数：8

共 20 条

[11] STEREOCONTROLLED SYNTHESIS OF 2,5-LINKED MONOTETRAHYDROFURAN UNITS OF ACETOGENINS [J].