NEW PYRIDAZINONES - SYNTHESIS AND CORRELATION BETWEEN STRUCTURE AND ALPHA-BLOCKING ACTIVITY

被引：13

作者：

CORSANO, S

SCAPICCHI, R

STRAPPAGHETTI, G

MARUCCI, G

PAPARELLI, F

机构：

[1] UNIV PERUGIA,INST PHARMACEUT CHEM,I-06100 PERUGIA,ITALY

[2] UNIV CAMERINO,DEPT CHEM SCI,I-62032 CAMERINO,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 7-8期

关键词：

ALPHA-ADRENOCEPTORS; PYRIDAZINONES; ALPHA-ANTAGONIST STRUCTURE ACTIVITY RELATIONSHIP; RAT VAS DEFERENS;

D O I：

10.1016/0223-5234(93)90097-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of 5-(4-piperazinyl)-3(2H)-pyridazinone has been reported. The blocking activity of these compounds was determined on the pre- and postsynaptic alpha-adrenoreceptors of isolated rat vas deferens.

引用

页码：647 / 651

页数：5

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