BENZYLPENICILLIN METHYL PHOSPHATE - A PENICILLIN PRODRUG THAT INACTIVATED RTEM BETA-LACTAMASE

被引：5

作者：

SONG, YH ^{[1
]}

KLUGER, R ^{[1
]}

机构：

[1] UNIV TORONTO, DEPT CHEM, LASH MILLER CHEM LABS, TORONTO M5S 1A1, ONTARIO, CANADA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(01)80335-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Benzylpenicillin methyl phosphate (BPMP, 1), hydrolyzes slowly to produce benzylpencillin and methyl phosphate. BPMP is a substrate and inactivator of E coli RTEM beta-lactamase. A competitive inhibitor of beta-lactamase protects the enzyme from inactivation by BPMP. It is proposed that BPMP acylates the epsilon-amino group of Lys-234 of the enzyme.

引用

页码：1225 / 1228

页数：4

共 18 条

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