ATHEROSCLEROSIS DECREASED PROSTACYCLIN FORMATION IN RABBIT LUNGS AND KIDNEYS

被引：26

作者：

DEMBINSKAKIEC, A

RUCKER, W

SCHONHOFER, PS

机构：

[1] Department für Pharmakologie und Toxikologie, Abt. II, Medizinische Hochschule Hannover, D-3000 Hannover 61

来源：

PROSTAGLANDINS | 1979年 / 17卷 / 06期

关键词：

D O I：

10.1016/0090-6980(79)90056-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolism of arachidonic acid (AA) was studied in perfused lungs and kidneys of normal and atherosclerotic rabbits by determination of PGE2, PGF2α and the stable metabolites of PGI2 (6-keto-PGF1α) and TXA2 (TXB2). PGI2 was the main AA metabolite formed by normal lungs and kidneys. Atherosclerosis reduced the formation of PGI2 by about 50 % in both organs. TXA2 formation was similarily decreased in lungs. In kidneys, the decrease in PGI2 formation was accompanied by an increase in PGE2 formation. © 1979.

引用

页码：831 / 838

页数：8