INFECTION-RESISTANCE OF SURFACE-MODIFIED CATHETERS WITH EITHER SHORT-LIVED OR PROLONGED ACTIVITY

被引：47

作者：

SAMPATH, LA ^{[1
]}

CHOWDHURY, N ^{[1
]}

CARAOS, L ^{[1
]}

MODAK, SM ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG, DEPT SURG, NEW YORK, NY 10032 USA

来源：

JOURNAL OF HOSPITAL INFECTION | 1995年 / 30卷 / 03期

关键词：

BACTERIAL ADHESION; SURFACE MODIFIED CATHETERS;

D O I：

10.1016/S0195-6701(95)90315-1

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

It has been suggested that the invasion of microbes into the catheter tract occurs mainly at the time of catheter insertion. To investigate whether the presence of an antimicrobial environment during the initial period after insertion is sufficient to reduce the risk of subsequent catheter colonization and infection, we evaluated the use of benzalkonium chloride-heparin bonded (BZK-hep) central venous catheters, which exhibit short-lived surface antimicrobial activity, using a rat subcutaneous model. Bacterial adherence on these catheters was determined, seven days after challenging the insertion site with 10(6) cfu of Staphylococcus aureus. A chlorhexidine-silver sulphadiazine impregnated catheter (Arrowg(+)ard), with longer lasting surface antimicrobial activity, and a hydrophilic coated catheter ('Hydrocath'), were evaluated simultaneously for comparison. Unlike Arrowg(+)ard antiseptic catheters, BZK-hep 'Hydrocath' and control catheters had significant bacterial adherence on their surface. Arrowg(+)ard catheters were colonized in 19% of the animals compared with 100% in all the other groups (P<0.05; mean cfu cm(-2): control=1.3 x 10(6), BZK-hep=4.3 x 10(5), Hydrocath=2 x 10(5), Arrowg(+)ard=71). Our results indicate that catheters with short-lived surface antimicrobial activity are unlikely to provide long-term protection against catheter-related infection. The efficacy of Arrowg(+)ard catheters may be due to the initial high rate of kill and prolonged antimicrobial activity.

引用

页码：201 / 210

页数：10

共 34 条

[11] Surenderjit, Nelson, Acosta, Check, Puri, Catheter colonization and bacteremia with pulmonary and arterial catheters, Crit Care Med, 10, pp. 736-739, (1982)
[12] Pemberton, Lyman, Lander, Covinsky, Sepsis from triple vs. single-lumen catheters during total parenteral nutrition in surgical or critically ill patients, Arch Surg, 121, pp. 591-637, (1986)
[13] Kristinsson, Adherence of Staphylococci to intravascular catheters, J Med Microbiol, 28, pp. 249-257, (1989)
[14] Mermel, Stolz, Maki, Surface antimicrobial activity of heparin-bonded and antiseptic-impregnated vascular catheters, J Infect Dis, 167, pp. 920-924, (1993)
[15] Guida, Frugard, Roberts, In vitro antimicrobial activity associated with Baxter-Edwards AMC intravascular catheters, Proceedings of the General Meeting of the American Society for Microbiology, (1989)
[16] Roberts, Frugard, Guida, In vivo antimicrobial activity associated with Baxter-Edwards AMC intravascular catheters in a dermal tunnel infection model, Proceedings of the General Meeting of the American Society for Microbiology, (1989)
[17] Bach, Bohrer, Motsch, Martin, Geiss, Sonntag, Prevention of catheter-related infections by antiseptic bonding, J Surg Res, 55, pp. 640-646, (1993)
[18] Greenfeld, Sampath, Popilskis, Brunnert, Stylianos, Modak, Decreased bacterial adherence and biofilm formation on chlorhexidine and silver sulfadiazineimpregnated central venous catheters implanted in swine, Crit Care Med, 23, pp. 894-900, (1995)
[19] Maki, Wheeler, Stolz, Study of a novel antiseptic-coated central venous catheter, Crit Care Med, 19, (1991)
[20] Clemence, Jernigan, Titus, Duani, Farr, A study of antiseptic impregnated central venous catheter for prevention of bloodstream infection (abstract 1624), Program and Abstract of the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, (1993)

← 1 2 3 4 →