MITOCHONDRIAL-DNA MUTATIONS IN NORMAL AND TUMOR-TISSUES FROM BREAST-CANCER PATIENTS

被引：81

作者：

BIANCHI, MS ^{[1
]}

BIANCHI, NO ^{[1
]}

BAILLIET, G ^{[1
]}

机构：

[1] IMBICE,RA-1900 LA PLATA,ARGENTINA

来源：

CYTOGENETICS AND CELL GENETICS | 1995年 / 71卷 / 01期

关键词：

D O I：

10.1159/000134072

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have characterized the mtDNA in normal and breast cancer tissues from seven patients. Both types of tissue showed point mutation heteroplasmies and extensive deletions of the mtDNA. The analysis of these polymorphisms allowed us to infer the mtDNA composition of the breast cell that underwent malignant transformation.

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页码：99 / 103

页数：5

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