PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION FROM COMPLEMENTARY-DNA OF A BRAIN CALCIUM-CHANNEL

被引：771

作者：

MORI, Y

FRIEDRICH, T

KIM, MS

MIKAMI, A

NAKAI, J

RUTH, P

BOSSE, E

HOFMANN, F

FLOCKERZI, V

FURUICHI, T

MIKOSHIBA, K

IMOTO, K

TANABE, T

NUMA, S

机构：

[1] KYOTO UNIV, FAC MED, DEPT MED CHEM, KYOTO 606, JAPAN

[2] KYOTO UNIV, FAC MED, DEPT MOLEC GENET, KYOTO 606, JAPAN

[3] UNIV SAARLAND, FAK MED, INST MED BIOCHEM, W-6650 HOMBURG, GERMANY

[4] NATL INST BASIC BIOL, DIV BEHAV & NEUROBIOL, OKAZAKI, AICHI 444, JAPAN

[5] OSAKA UNIV, INST PROT RES, DIV REGULAT MACROMOLEC FUNCT, SUITA, OSAKA 565, JAPAN

来源：

NATURE | 1991年 / 350卷 / 6317期

关键词：

D O I：

10.1038/350398a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The primary structure of a voltage-dependent calcium channel from rabbit brain has been deduced by cloning and sequencing the complementary DNA. Calcium channel activity expressed from the cDNA is dramatically increased by coexpression of the alpha-2 and beta-subunits, known to be associated with the dihydropyridine receptor. This channel is a high voltage-activated calcium channel that is insensitive both to nifedipine and to omega-conotoxin. We suggest that it is expressed predominantly in cerebellar Purkinje cells and granule cells.

引用

页码：398 / 402

页数：5

共 37 条

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