EFFECT OF THE SULFONYLUREA GLYBURIDE ON SUPEROXIDE-DISMUTASE ACTIVITY IN ALLOXAN-INDUCED DIABETIC RAT HEPATOCYTES

被引：12

作者：

ALTAN, N

ONGUN, CO

HASANOGLU, E

ENGIN, A

TUNCER, C

SINDEL, S

机构：

[1] GAZI UNIV,FAC MED,DEPT INTERNAL MED,ANKARA 06510,TURKEY

[2] GAZI UNIV,FAC MED,DEPT SURG,ANKARA 06510,TURKEY

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 1994年 / 22卷 / 2-3期

关键词：

GLYBURIDE; SUPEROXIDE DISMUTASE (SOD); DIABETES; RAT LIVER;

D O I：

10.1016/0168-8227(94)90041-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the present study we administrated glyburide (glibenclamide) to type 2 (NIDDM) diabetic rats and determined the effect of such treatment on liver superoxide dismutase (SOD) activity. Hepatic SOD activity was significantly reduced in diabetic animals. Glyburide treatment of diabetic rats for 4 weeks corrected the changes observed in diabetic liver. In addition, blood glucose levels of untreated diabetic rats decreased following glyburide treatment. Administration of glyburide to diabetic rats reversed the diabetes-induced changes, suggesting that glyburide may directly increase liver SOD enzyme activity.

引用

页码：95 / 98

页数：4

共 24 条

[1] INSULIN-LIKE AND INSULIN-ENHANCING EFFECTS OF THE SULFONYLUREA GLYBURIDE ON RAT ADIPOSE GLYCOGEN-SYNTHASE [J].