ASYMMETRIC-SYNTHESIS OF (-)-(1R,2S)-CISPENTACIN AND RELATED CIS-2-AMINO AND TRANS-2-AMINO CYCLOPENTANE-1-CARBOXYLIC AND CYCLOHEXANE-1-CARBOXYLIC ACIDS

被引：90

作者：

DAVIES, SG

ICHIHARA, O

LENOIR, I

WALTERS, IAS

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 11期

关键词：

D O I：

10.1039/p19940001411

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The antifungal antibiotic (-)-(1R,2S)-2-aminocyclopentane-1-carboxylic acid (cispentacin) 8 and its cyclohexane homologue 14 have been prepared utilizing the highly stereoselective conjugate addition of homochiral lithium N-benzyl-N-alpha-methylbenzylamide 5. The corresponding trans-beta-amino acids 10 and 16 were also prepared via the selective epimerization of the cis-beta-amino ester conjugate addition products.

引用

页码：1411 / 1415

页数：5

共 20 条

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