SYNTHESIS OF CARBOXYLATED PYRROLIDINE DERIVATIVES VIA 1,3-DIPOLAR CYCLOADDITIONS OF HOMOCHIRAL DOUBLE-STABILIZED E-AZOMETHINE YLIDS

被引：34

作者：

HARWOOD, LM

LILLEY, IA

机构：

[1] Dyson Perrins Laboratory, University of Oxford, Oxford, OX1 3QY, South Parks Road

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 07期

关键词：

D O I：

10.1016/0957-4166(95)00198-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The preparation and subsequent diastereoselective 1,3- dipolar cycloaddition of E-carboethoxy-substituted azomethine ylids derived by condensing 5-(S)-phenylmorpholinone (1) with ethyl glyoxalate is described. Removal of the chiral template furnishes enantiomerically pure pyrrolidine-2,5-dicarboxylate derivatives.

引用

页码：1557 / 1560

页数：4

共 10 条

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[2] DEVELOPMENT OF CHIRAL STABILIZED AZOMETHINE YLIDES - A CHIRAL MEMORY RELAY SYSTEM
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[3] DEVELOPMENT OF A CHIRAL STABILIZED AZOMETHINE YLID - A CHIRAL RELAY SYSTEM
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[5] SYNTHESIS OF HOMOCHIRAL ALPHA-AMINO-ACIDS BY REDUCTIVE AMINATION OF ALPHA-KETOACIDS VIA 3-SUBSTITUTED-5-PHENYL-3,4-DEHYDROMORPHOLIN-2-ONES - SYNTHESIS OF (S)-2-AMINOBUTANOIC AND (R)-2-AMINOBUTANOIC ACID
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[6] HARWOOD LM, 1993, SYNLETT, P777
[7] ASYMMETRIC CYCLOADDITIONS OF ALDEHYDES TO STABILIZED AZOMETHINE YLIDS - ENANTIOCONTROLLED CONSTRUCTION OF BETA-HYDROXY-ALPHA-AMINO ACID-DERIVATIVES
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[8] ENANTIOCONTROLLED CONSTRUCTION OF BICYCLIC PROLINE DERIVATIVES VIA ONE-POT GENERATION AND INTRAMOLECULAR TRAPPING OF CHIRAL STABILIZED AZOMETHINE YLIDS
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[9] HARWOOD LM, 1993, TETRAHEDRON LETT, P6603
[10] ASYMMETRIC [1,3]-DIPOLAR CYCLOADDITION REACTIONS - SYNTHESIS OF HIGHLY SUBSTITUTED PROLINE DERIVATIVES
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