FOLATE ANALOGS .32. SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-DESAMINO-2-METHYL-N10-PROPARGYL-5,8-DIDEAZAFOLIC ACID AND RELATED-COMPOUNDS

被引:44
作者
PATIL, SD
JONES, C
NAIR, MG
GALIVAN, J
MALEY, F
KISLIUK, RL
GAUMONT, Y
DUCH, D
FERONE, R
机构
[1] UNIV S ALABAMA, DEPT BIOCHEM, MOBILE, AL 36688 USA
[2] NEW YORK STATE DEPT HLTH, WADSWORTH CTR LABS & RES, ALBANY, NY 12201 USA
[3] TUFTS UNIV, BOSTON, MA 02111 USA
[4] BURROUGHS WELLCOME CO, RES TRIANGLE PK, NC 27709 USA
关键词
D O I
10.1021/jm00126a023
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1284 / 1289
页数:6
相关论文
共 19 条
  • [1] CHENG YC, 1985, CANCER RES, V45, P598
  • [2] GALIVAN J, 1981, CANCER RES, V41, P1757
  • [3] HUGHES LR, 1988, P AM ASSOC CANC RES, V29, P286
  • [4] HUGHES LR, Patent No. 2188319
  • [5] JACKMAN AL, 1988, P AM ASSOC CANC RES, V29, P287
  • [6] JOHNSON TB, 1988, CANCER RES, V48, P2426
  • [7] A POTENT ANTI-TUMOR QUINAZOLINE INHIBITOR OF THYMIDYLATE SYNTHETASE - SYNTHESIS, BIOLOGICAL PROPERTIES AND THERAPEUTIC RESULTS IN MICE
    JONES, TR
    CALVERT, AH
    JACKMAN, AL
    BROWN, SJ
    JONES, M
    HARRAP, KR
    [J]. EUROPEAN JOURNAL OF CANCER, 1981, 17 (01) : 11 - 19
  • [8] QUINAZOLINE ANTIFOLATES INHIBITING THYMIDYLATE SYNTHASE - VARIATION OF THE N-10 SUBSTITUENT
    JONES, TR
    CALVERT, AH
    JACKMAN, AL
    EAKIN, MA
    SMITHERS, MJ
    BETTERIDGE, RF
    NEWELL, DR
    HAYTER, AJ
    STOCKER, A
    HARLAND, SJ
    DAVIES, LC
    HARRAP, KR
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (10) : 1468 - 1476
  • [9] THE ABSENCE OF GAMMA-GLUTAMYL-TRANSFERASE ACTIVITY IN TRANSPORT-DEPENDENT METHOTREXATE-RESISTANT HEPATOMA-CELLS
    KRUGERMCDERMOTT, C
    JOHNSON, TB
    REJ, R
    VANDERHOEVEN, T
    NAIR, MG
    GALIVAN, J
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1987, 40 (06) : 835 - 839
  • [10] MORAN RG, 1985, 2ND P WORKSH FOL ANT, P51