ACQUISITION AND INVASIVENESS OF DIFFERENT SEROTYPES OF STREPTOCOCCUS-PNEUMONIAE IN YOUNG-CHILDREN

被引：100

作者：

SMITH, T ^{[1
]}

LEHMANN, D ^{[1
]}

MONTGOMERY, J ^{[1
]}

GRATTEN, M ^{[1
]}

RILEY, ID ^{[1
]}

ALPERS, MP ^{[1
]}

机构：

[1] PAPUA NEW GUINEA INST MED RES, POB 60, GOROKA, PAPUA N GUINEA

来源：

EPIDEMIOLOGY AND INFECTION | 1993年 / 111卷 / 01期

关键词：

D O I：

10.1017/S0950268800056648

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Rates of acquisition and mean duration of nasal carriage of different serotypes of Streptococcus pneumoniae have been estimated by fitting a stochastic model to longitudinal carriage data in children from Papua New Guinea. Immunogenicity and two indices of relative invasiveness were determined for each serotype. Immunogenic serotypes were less frequently acquired and were carried for shorter periods, but no relationship between immunogenicity and invasiveness was apparent using either index of invasiveness. Frequent invasion was associated with a high acquisition rate and high frequency and prolonged duration of carriage. Carriage studies can provide a broad indication of which serotypes cause invasive disease but not the proportion of disease due to individual serotypes; some serotypes which cause invasive disease (e.g. serotype 46) are not found even in extensive carriage studies. The antibiotic resistance of carriage organisms, however, does approximate the resistance patterns of invasive organisms and thus may be used to monitor changing patterns of antimicrobial susceptibility in the community.

引用

页码：27 / 39

页数：13