LIVE ATTENUATED PSEUDORABIES VIRUS EXPRESSING ENVELOPE GLYCOPROTEIN-E1 OF HOG-CHOLERA VIRUS PROTECTS SWINE AGAINST BOTH PSEUDORABIES AND HOG-CHOLERA

被引：207

作者：

VANZIJL, M

WENSVOORT, G

DEKLUYVER, E

HULST, M

VANDERGULDEN, H

GIELKENS, A

BERNS, A

MOORMANN, R

机构：

[1] CENT VET INST,DEPT VIROL,HOUTRIBWEG 39,8221 RA LELYSTAD,NETHERLANDS

[2] NETHERLANDS CANC INST,DIV MOLEC GENET,1066 CX AMSTERDAM,NETHERLANDS

[3] UNIV AMSTERDAM,DEPT BIOCHEM,AMSTERDAM,NETHERLANDS

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 05期

关键词：

D O I：

10.1128/JVI.65.5.2761-2765.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To investigate whether live attenuated pseudorabies virus (PRV) can be used as a vaccine vector, PRV recombinants that expressed envelope glycoprotein E1 of hog cholera virus (HCV) were generated. Pigs inoculated with these recombinants developed high levels of neutralizing antibodies against PRV and HCV and were protected against both pseudorabies and hog cholera (classical swine fever).

引用

收藏

页码：2761 / 2765

页数：5

相关论文

共 31 条

[21] PSEUDORABIES VIRUS AS A LIVE VIRUS VECTOR FOR EXPRESSION OF FOREIGN GENES [J].

THOMSEN, DR ;

MAROTTI, KR ;

PALERMO, DP ;

POST, LE .

GENE, 1987, 57 (2-3) :261-265

[22]

VANOIRSCHOT J, 1986, DISEASES SWINE, P289

[23] IDENTIFICATION OF 2 GENES IN THE UNIQUE SHORT REGION OF PSEUDORABIES VIRUS - COMPARISON WITH HERPES-SIMPLEX VIRUS AND VARICELLA-ZOSTER VIRUS [J].

VANZIJL, M ;

VANDERGULDEN, H ;

DEWIND, N ;

GIELKENS, A ;

BERNS, A .

JOURNAL OF GENERAL VIROLOGY, 1990, 71 :1747-1755

[24] REGENERATION OF HERPESVIRUSES FROM MOLECULARLY CLONED SUBGENOMIC FRAGMENTS [J].

VANZIJL, M ;

QUINT, W ;

BRIAIRE, J ;

DEROVER, T ;

GIELKENS, A ;

BERNS, A .

JOURNAL OF VIROLOGY, 1988, 62 (06) :2191-2195

[25] IMMUNOAFFINITY PURIFICATION AND CHARACTERIZATION OF THE ENVELOPE PROTEIN-E1 OF HOG-CHOLERA VIRUS [J].

WENSVOORT, G ;

BOONSTRA, J ;

BODZINGA, BG .

JOURNAL OF GENERAL VIROLOGY, 1990, 71 :531-540

[26] CHARACTERIZATION OF PORCINE AND SOME RUMINANT PESTIVIRUSES BY CROSS-NEUTRALIZATION [J].

WENSVOORT, G ;

TERPSTRA, C ;

DEKLUYVER, EP .

VETERINARY MICROBIOLOGY, 1989, 20 (04) :291-306

[27] AN ENZYME-IMMUNOASSAY EMPLOYING MONOCLONAL-ANTIBODIES AND DETECTING SPECIFICALLY ANTIBODIES TO CLASSICAL SWINE FEVER VIRUS [J].

WENSVOORT, G ;

BLOEMRAAD, M ;

TERPSTRA, C .

VETERINARY MICROBIOLOGY, 1988, 17 (02) :129-140

[28] PRODUCTION OF MONOCLONAL-ANTIBODIES AGAINST SWINE FEVER VIRUS AND THEIR USE IN LABORATORY DIAGNOSIS [J].

WENSVOORT, G ;

TERPSTRA, C ;

BOONSTRA, J ;

BLOEMRAAD, M ;

VANZAANE, D .

VETERINARY MICROBIOLOGY, 1986, 12 (02) :101-108

[29] TOPOGRAPHICAL AND FUNCTIONAL MAPPING OF EPITOPES ON HOG-CHOLERA VIRUS WITH MONOCLONAL-ANTIBODIES [J].

WENSVOORT, G .

JOURNAL OF GENERAL VIROLOGY, 1989, 70 :2865-2876

[30] TOGAVIRIDAE [J].

WESTAWAY, EG ;

BRINTON, MA ;

GAIDAMOVICH, SY ;

HORZINEK, MC ;

IGARASHI, A ;

KAARIAINEN, L ;

LVOV, DK ;

PORTERFIELD, JS ;

RUSSELL, PK ;

TRENT, DW .

INTERVIROLOGY, 1985, 24 (03) :125-139

← 1 2 3 4 →