THE LOW AFFINITY COMPONENT OF [H-3] CLONIDINE BINDING IS ABSENT IN THE PREFRONTAL CORTEX OF PRESUMPTIVE SUICIDE VICTIMS

被引：7

作者：

ANDORN, AC

机构：

[1] LOUISIANA STATE UNIV,SCH MED,DEPT PSYCHIAT,SHREVEPORT,LA 71130

[2] LOUISIANA STATE UNIV,SCH MED,DEPT PHARMACOL,SHREVEPORT,LA 71130

来源：

BRAIN RESEARCH | 1991年 / 568卷 / 1-2期

关键词：

DEPRESSION; H-3]CLONIDINE BINDING; ALPHA-2-ADRENERGIC RECEPTOR; HUMAN PREFRONTAL CORTEX; SUICIDE; HYPOTHALAMIC-PITUITARY-ADRENAL AXIS;

D O I：

10.1016/0006-8993(91)91408-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dysfunction in alpha-adrenergic receptor systems has been implicated to be of etiologic significance in depressive illness. The alpha(2)-adrenergic ligand [H-3]clonidine labels at least two sets of binding sites in normal human prefrontal cortex. We now report that the lower affinity component of [H-3]clonidine binding is apparently absent in the prefrontal cortices of presumptive suicide victims.

引用

页码：276 / 278

页数：3