REM-SLEEP BEHAVIOR DISORDER - AN UPDATE ON A SERIES OF 96 PATIENTS AND A REVIEW OF THE WORLD LITERATURE

被引:230
作者
SCHENCK, CH
HURWITZ, TD
MAHOWALD, MW
机构
[1] HENNEPIN CTY MED CTR,DEPT PSYCHIAT,MINNEAPOLIS,MN 55415
[2] HENNEPIN CTY MED CTR,DEPT NEUROL,MINNEAPOLIS,MN 55415
[3] UNIV MINNESOTA,SCH MED,MINNEAPOLIS,MN 55455
关键词
CLONAZEPAM; DREAM DISORDERS; MOTOR DYSCONTROL; PARADOXICAL SLEEP WITHOUT ATONIA; PARASOMNIAS; REM SLEEP BEHAVIOR DISORDER; SLOW-WAVE (DELTA-WAVE) SLEEP;
D O I
10.1111/j.1365-2869.1993.tb00093.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
REM sleep behaviour disorder (RBD) is an injurious clinical disorder of attempted dream-enactment ('oneirism') in humans which has a corresponding experimental animal model involving dorsolateral pontine tegmental lesions in cats. To date, our sleep disorders centre has collected data on 96 chronic RBD cases which can be compared with pooled data on 70 chronic RBD cases from other centres contained in 26 reports published in the world literature since 1985, when our initial cases were first reported. The data from our centre and from other centres demonstrate a male predominance in RBD (87.5% vs 63.5%); indicate a similar mean age of RBD onset (52.4 y vs 55.9 y); contain substantial numbers of diverse central nervous system disorders causally associated with RBD (47.9% vs 60.0%); and identify clonazepam treatment as being very effective in controlling both the (violent) dream and sleep behavioural disturbances of RBD. Our centre's data additionally reveal an 80% prevalence of elevated stage 3/4 (slow-wave) sleep% for age in RBD, and reveal a frequent presence of periodic and aperiodic limb movements during NREM sleep. Thus, RBD in humans is a complex syndrome in which there is generalized REM and NREM sleep motor dyscontrol, as was originally observed in the animal RBD model by Jouvet and Delorme in 1965.
引用
收藏
页码:224 / 231
页数:8
相关论文
共 85 条
[51]  
Sakai K., 1981, BRAIN MECHANISMS PER, P405
[52]   OLIVOPONTOCEREBELLAR DEGENERATION, ABNORMAL SLEEP, AND REM-SLEEP WITHOUT ATONIA [J].
SALVA, MAQ ;
GUILLEMINAULT, C .
NEUROLOGY, 1986, 36 (04) :576-577
[53]  
SASTRE JP, 1979, PHYSIOL BEHAV, V22, P979
[54]  
Schenck C, 1992, SLEEP RES, V21, P257
[55]   PROMINENT EYE-MOVEMENTS DURING NREM SLEEP AND REM-SLEEP BEHAVIOR DISORDER ASSOCIATED WITH FLUOXETINE TREATMENT OF DEPRESSION AND OBSESSIVE-COMPULSIVE DISORDER [J].
SCHENCK, CH ;
MAHOWALD, MW ;
KIM, SW ;
OCONNOR, KA ;
HURWITZ, TD .
SLEEP, 1992, 15 (03) :226-235
[56]  
SCHENCK CH, 1989, AM J PSYCHIAT, V146, P1166
[57]   RAPID EYE-MOVEMENT SLEEP BEHAVIOR DISORDER - A TREATABLE PARASOMNIA AFFECTING OLDER ADULTS [J].
SCHENCK, CH ;
BUNDLIE, SR ;
PATTERSON, AL ;
MAHOWALD, MW .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1987, 257 (13) :1786-1789
[58]   MOTOR DYSCONTROL IN NARCOLEPSY - RAPID-EYE-MOVEMENT (REM) SLEEP WITHOUT ATONIA AND REM-SLEEP BEHAVIOR DISORDER [J].
SCHENCK, CH ;
MAHOWALD, MW .
ANNALS OF NEUROLOGY, 1992, 32 (01) :3-10
[59]   CHRONIC BEHAVIORAL-DISORDERS OF HUMAN REM-SLEEP - A NEW CATEGORY OF PARASOMNIA [J].
SCHENCK, CH ;
BUNDLIE, SR ;
ETTINGER, MG ;
MAHOWALD, MW .
SLEEP, 1986, 9 (02) :293-308
[60]  
SCHENCK CH, 1988, AM J PSYCHIAT, V145, P652