A PRELIMINARY EVALUATION OF THE PERFORMANCE OF THE MUTA(TM) MOUSE (LACZ) AND BIG BLUE(TM) (LACI) TRANSGENIC MOUSE MUTATION ASSAYS

被引：71

作者：

MORRISON, V ^{[1
]}

ASHBY, J ^{[1
]}

机构：

[1] ZENECA CENT TOXICOL LAB,N MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND

来源：

MUTAGENESIS | 1994年 / 9卷 / 04期

关键词：

D O I：

10.1093/mutage/9.4.367

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

All of the published mutagenicity data generated using the Muta(TM) Mouse (lacZ) and the Big Blue(TM) (lacl) transgenic mouse mutation assays have been re-presented in a standard format. To date, 26 chemicals have been evaluated in one or other of the assays, and eight tissues have been sampled. The present analysis should expedite the further validation of these assays. In particular, it is suggested that data on the present 26 chemicals should be consolidated rather than the generation of partial data sets on additional chemicals.

引用

页码：367 / 375

页数：9

共 27 条

[1] TRANSGENIC MOUSE MUTATION ASSAYS - POTENTIAL FOR CONFUSION OF GENOTOXIC AND NONGENOTOXIC CARCINOGENESIS - A PROPOSED SOLUTION [J].

ASHBY, J ;

LEIGIBEL, U .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1992, 20 (03) :145-147

[2] CORRELATION OF CARCINOGENIC POTENCY WITH MOUSE-SKIN P-32 POSTLABELING AND MUTA-RMOUSE LAC Z- MUTATION DATA FOR DMBA AND ITS K-REGION SULFUR ISOSTERE - COMPARISON WITH ACTIVITIES OBSERVED IN STANDARD GENOTOXICITY ASSAYS [J].

ASHBY, J ;

BRUSICK, D ;

MYHR, BC ;

JONES, NJ ;

PARRY, JM ;

NESNOW, S ;

PATON, D ;

TINWELL, H ;

ROSENKRANZ, HS ;

CURTI, S ;

GILMAN, D ;

CALLANDER, RD .

MUTATION RESEARCH, 1993, 292 (01) :25-40

[3] DOSING REGIMENS FOR TRANSGENIC ANIMAL MUTAGENESIS ASSAYS [J].

ASHBY, J ;

LIEGIBEL, U .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1993, 21 (02) :120-121

[4]

ASHBY J, 1994, IN PRESS MUTAGENESIS

[5] LACK OF PREDICTIVITY OF BONE-MARROW MICRONUCLEUS TEST VERSUS TESTIS MICRONUCLEUS TEST - COMPARISON WITH 4 CARCINOGENS [J].

CLIET, I ;

MELCION, C ;

CORDIER, A .

MUTATION RESEARCH, 1993, 292 (02) :105-111

[6]

Glickman B. W., 1993, Environmental and Molecular Mutagenesis, V21, P1

[7] OVERVIEW OF THE WORKSHOPS ON STATISTICAL-ANALYSIS OF MUTATION DATA FROM TRANSGENIC MICE [J].

GORELICK, NJ ;

THOMPSON, ED .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1994, 23 (01) :12-16

[8] APPLICATION OF GALACTOSE-SENSITIVE ESCHERICHIA-COLI STRAINS AS SELECTIVE HOSTS FOR LACZ- PLASMIDS [J].

GOSSEN, JA ;

MOLIJN, AC ;

DOUGLAS, GR ;

VIJG, J .

NUCLEIC ACIDS RESEARCH, 1992, 20 (12) :3254-3254

[9] EFFICIENT RESCUE OF INTEGRATED SHUTTLE VECTORS FROM TRANSGENIC MICE - A MODEL FOR STUDYING MUTATIONS INVIVO [J].

GOSSEN, JA ;

DELEEUW, WJF ;

TAN, CHT ;

ZWARTHOFF, EC ;

BERENDS, F ;

LOHMAN, PHM ;

KNOOK, DL ;

VIJG, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) :7971-7975

[10] CAN NONGENOTOXIC CARCINOGENS BE DETECTED WITH THE LACI TRANSGENIC MOUSE MUTATION ASSAY [J].

GUNZ, D ;

SHEPHARD, SE ;

LUTZ, WK .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1993, 21 (03) :209-211

← 1 2 3 →