DO WE KNOW THE SITE OF ACTION OF CYCLOSPORINE

被引:46
作者
ERLANGER, BF
机构
[1] Bernard F. Erlanger is at the Dept of Microbiology, Columbia University Health Sciences Center, New York, NY 10032
来源
IMMUNOLOGY TODAY | 1992年 / 13卷 / 12期
关键词
D O I
10.1016/0167-5699(92)90023-Z
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The site and mode of action of cyclosporin A (CsA) have been subjects of study ever since CsA was discovered and demonstrated to be a selective suppressor of allograft rejection. In this article, Bernard Erlanger traces progress to date and presents evidence that the site of action is not cytoplasmic cyclophilin but a lymphocyte cell-surface receptor that might be related in structure to cyclophilin.
引用
收藏
页码:487 / 490
页数:4
相关论文
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