机构:Bernard F. Erlanger is at the Dept of Microbiology, Columbia University Health Sciences Center, New York, NY 10032
ERLANGER, BF
机构:
[1] Bernard F. Erlanger is at the Dept of Microbiology, Columbia University Health Sciences Center, New York, NY 10032
来源:
IMMUNOLOGY TODAY
|
1992年
/
13卷
/
12期
关键词:
D O I:
10.1016/0167-5699(92)90023-Z
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The site and mode of action of cyclosporin A (CsA) have been subjects of study ever since CsA was discovered and demonstrated to be a selective suppressor of allograft rejection. In this article, Bernard Erlanger traces progress to date and presents evidence that the site of action is not cytoplasmic cyclophilin but a lymphocyte cell-surface receptor that might be related in structure to cyclophilin.