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DO WE KNOW THE SITE OF ACTION OF CYCLOSPORINE

被引：46
作者：
ERLANGER, BF
机构：
[1] Bernard F. Erlanger is at the Dept of Microbiology, Columbia University Health Sciences Center, New York, NY 10032
来源：
IMMUNOLOGY TODAY | 1992年 / 13卷 / 12期
关键词：
D O I：
10.1016/0167-5699(92)90023-Z
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The site and mode of action of cyclosporin A (CsA) have been subjects of study ever since CsA was discovered and demonstrated to be a selective suppressor of allograft rejection. In this article, Bernard Erlanger traces progress to date and presents evidence that the site of action is not cytoplasmic cyclophilin but a lymphocyte cell-surface receptor that might be related in structure to cyclophilin.
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页码：487 / 490
页数：4
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