ESTIMATION OF IMPURITY PROFILES IN DRUGS AND RELATED MATERIALS .11. THE ROLE OF CHROMATOGRAPHIC AND SPECTROSCOPIC METHODS IN THE ESTIMATION OF SIDE-REACTIONS IN DRUG SYNTHESES

被引：14

作者：

GOROG, S

BALOGH, G

CSEHI, A

CSIZER, E

GAZDAG, M

HALMOS, ZS

HEGEDUS, B

HERENYI, B

HORVATH, P

LAUKO, A

机构：

[1] Chemical Works of G. Richter Ltd, H-1475 Budapest

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 11-12期

关键词：

IMPURITY PROFILING; ESTIMATION OF SIDE-REACTIONS; 19-NOR-STEROIDS; FLUMECINOL; DANAZOL; FAMOTIDINE; PIPECURONIUM BROMIDE;

D O I：

10.1016/0731-7085(93)80107-C

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Impurities in drugs are classified on the basis of the types of side-reactions in drug syntheses resulting in their formation. This is shown by summarizing the authors' earlier results in the field of impurity profiling of 19-nor-steroids, ethynodiol diacetate, mazipredone, pipecuronium bromide, flumecinol, enalapril, pyridinol carbamate, phenylbutazone, thymotrinan and some new results related to danazol and famotidine.

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页码：1219 / 1226

页数：8

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