ESTIMATION OF IMPURITY PROFILES OF DRUGS AND RELATED MATERIALS .9. HPLC INVESTIGATION OF FLUMECINOL

被引：12

作者：

GOROG, S

HERENYI, B

RENYEI, M

机构：

[1] Chemical Works G. Richter Ltd, H-1475 Budapest

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1992年 / 10卷 / 10-12期

关键词：

IMPURITY PROFILING; HPLC; CHIRAL SEPARATION; SPECTRAL CONVOLUTION; FLUMECINOL; 4'-METHYLFLUMECINOL;

D O I：

10.1016/0731-7085(91)80088-Q

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Two HPLC systems have been developed for the investigation of flumecinol (3-trifluoromethly-alpha-ethyl-benzhydrol). The reversed-phase system (LiChrosorb RP-18; methanol-water, 7:3, v/v) enables the isolation and identification of the impurities. The chiral system (Chiralcel OD; hexane-2-propanol, 98:2, v/v) separates the enantiomers of flumecinol and its impurities. The potential of spectral convolution in peak identification in HPLC impurity profiling is demonstrated by an example involving the identification of the 4'-methyl-analogue of flumecinol.

引用

页码：831 / 835

页数：5

共 7 条

[1] ANALYSIS OF STEROIDS .38. THE USE OF HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH DIODE-ARRAY UV DETECTION FOR ESTIMATING IMPURITY PROFILES OF STEROID DRUGS [J].