MEASLES VIRUS-INDUCED CHANGES IN LEUKOCYTE FUNCTION ANTIGEN-1 EXPRESSION AND LEUKOCYTE AGGREGATION - POSSIBLE ROLE IN MEASLES-VIRUS PATHOGENESIS

被引：18

作者：

ATTIBELE, N

WYDE, PR

TRIAL, J

SMOLE, SC

SMITH, CW

ROSSEN, RD

机构：

[1] BAYLOR COLL MED,DEPT MICROBIOL & IMMUNOL,HOUSTON,TX 77030

[2] BAYLOR COLL MED,DEPT PEDIAT,HOUSTON,TX 77030

[3] VET AFFAIRS MED CTR,AIDS & HIV INFECT RES CTR,HOUSTON,TX 77030

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 02期

关键词：

D O I：

10.1128/JVI.67.2.1075-1079.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Measles virus (MV) infection of U937 cell or peripheral blood leukocyte cultures was shown to induce changes in the expression of leukocyte function antigen 1 (LFA-1) and cause marked aggregation of these cells. Addition of selected monoclonal antibodies specific for LFA-1 epitopes that did not neutralize MV in standard neutralization assays were found to block both virus-induced leukocyte aggregation and virus dissemination. These data suggest that MV modulation of LFA-1 expression on leukocytes may be an important step in MV pathogenesis.

引用

页码：1075 / 1079

页数：5

共 24 条

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