Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study in the rat

被引：132

作者：

Ohishi, H

Nomura, S

Ding, YQ

Shigemoto, R

Wada, E

Kinoshita, A

Li, JL

Neki, A

Nakanishi, S

Mizuno, N

机构：

[1] KYOTO UNIV, FAC MED, DEPT MORPHOL BRAIN SCI, KYOTO 60601, JAPAN

[2] KYOTO UNIV, COLL MED TECHNOL, KYOTO 60601, JAPAN

[3] KYOTO UNIV, FAC MED, DEPT NEUROSURG, KYOTO 60601, JAPAN

[4] KYOTO UNIV, FAC MED, DEPT NEUROL, KYOTO 60601, JAPAN

[5] KYOTO UNIV, DEPT BIOL SCI, KYOTO 60601, JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 202卷 / 1-2期

关键词：

metabotropic glutamate receptors; mGluR7; antibody; immunohistochemistry; dorsal root ganglion; spinal cord; primary afferent fibers; L-2-amino-4-phosphonobutyrate;

D O I：

10.1016/0304-3940(95)12207-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An antibody which recognizes specifically a metabotropic glutamate receptor, mGluR7, was produced by using a trpE fusion protein containing a C-terminal sequence of rat mGluR7. Neuropil in laminae I and II of the dorsal horn of the rat, as well as many neuronal cell bodies in the dorsal root ganglion, showed mGluR7-like immunoreactivity; the immunoreactivity in neuropil was seen in axon terminals, which were filled with round synaptic vesicles and constituted axodendritic and axosomatic asymmetric synapses. The mGluR7-like immunoreactivity in laminae I and Il in the dorsal horn was reduced after dorsal rhizotomy. The results indicate that some axon terminals of the primary afferent fibers to laminae I and II of the dorsal horn are provided with mGluR7.

引用

页码：85 / 88

页数：4