SYSTEMIC PRODUCTION OF FOREIGN PEPTIDES ON THE PARTICLE SURFACE OF TOBACCO MOSAIC-VIRUS

被引：69

作者：

SUGIYAMA, Y ^{[1
]}

HAMAMOTO, H ^{[1
]}

TAKEMOTO, S ^{[1
]}

WATANABE, Y ^{[1
]}

OKADA, Y ^{[1
]}

机构：

[1] TEIKYO UNIV,DEPT BIOSCI,UTSUNOMIYA,TOCHIGI 320,JAPAN

来源：

FEBS LETTERS | 1995年 / 359卷 / 2-3期

关键词：

FOREIGN PEPTIDE; FUSED PROTEIN; VIRUS PARTICLE; TOBACCO MOSAIC VIRUS;

D O I：

10.1016/0014-5793(95)00054-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By using a new tobacco mosaic virus (TMV) vector [Hamamoto, H., et al, (1993) Bio/Technology 11, 930-932], we have constructed TMV particles which present three different kinds of epitopes, two of them from influenza virus hemagglutinin (HA), and one from human immunodeficiency virus type I (HIV-I) envelope protein, on the surface of the particles, Each of these TMV particles reacted with each anti-peptide antiserum, These results suggest that this TMV vector can be used as an antigen presentation system.

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页码：247 / 250

页数：4

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