TYROSINE KINASES - MODULAR SIGNALING ENZYMES WITH TUNABLE SPECIFICITIES

被引：46

作者：

SHOKAT, KM ^{[1
]}

机构：

[1] PRINCETON UNIV, DEPT BIOL MOLEC, PRINCETON, NJ 08544 USA

来源：

CHEMISTRY & BIOLOGY | 1995年 / 2卷 / 08期

关键词：

D O I：

10.1016/1074-5521(95)90183-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytoplasmic tyrosine kinases are composed of modular domains; one (SH1) has catalytic activity, the other two (SH2 and SH3) do not. Kinase specificity is largely determined by the binding preferences of the SH2 domain. Attaching the SH1 domain to a new SH2 domain, via protein-protein association or mutation, can thus dramatically change kinase function.

引用

页码：509 / 514

页数：6

共 36 条

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