INDUCTION OF IMMUNOLOGICAL TOLERANCE BY PORCINE LIVER ALLOGRAFTS

被引：761

作者：

CALNE, RY

SELLS, RA

PENA, JR

DAVIS, DR

MILLARD, PR

HERBERTSON, BM

BINNS, RM

DAVIES, DAL

机构：

[1] Department of Experimental Pathology, A. R. C. Institute of Animal Physiology

来源：

NATURE | 1969年 / 223卷 / 5205期

关键词：

D O I：

10.1038/223472a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Liver allografting experiments with pigs show that animals given no immunosuppression will survive for prolonged periods with orthotopic liver transplants. Similar animals can reject skin, kidneys and hearts rapidly. Orthotopic and accessory heterotopic liver allografts protect preferentially from rejection grafts of donor specific skin, kidney and possibly heart. Injected soluble liver antigen may also protect donor specific tissue from rejection. It is suggested that allogeneic liver can induce immunological tolerance in immunologically mature pigs. © 1969 Nature Publishing Group.

引用

页码：472 / +

页数：1

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