THE EFFECT OF 3 ANTIESTROGEN DRUGS ON CERVICAL-MUCUS QUALITY AND INVITRO SPERM CERVICAL-MUCUS INTERACTION IN OVULATORY WOMEN

被引：23

作者：

ACHARYA, U

IRVINE, DS

HAMILTON, MPR

TEMPLETON, AA

机构：

[1] Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen Maternity Hospital, Aberdeen AB9 2ZD, Cornhill Road

来源：

HUMAN REPRODUCTION | 1993年 / 8卷 / 03期

关键词：

ANTIESTROGENS; CERVICAL MUCUS; SPERM CERVICAL MUCUS INTERACTION;

D O I：

10.1093/oxfordjournals.humrep.a138067

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The anti-oestrogens, clomiphene citrate, tamoxifen and cyclofenil are commonly used in the treatment of female infertility. Their role in the management of anovulation is well established but there is continuing controversy about their relevance to other areas of management. We have studied the effects of each of these drugs on cervical mucus and sperm-cervical mucus interaction among 23 patients with unexplained infertility. Each patient received all three drugs in an alternative month treatment regime and in addition acted as her own control. The starting point in each patient was randomized. Luteinizing hormone (LH) and oestradiol were measured daily from day 10, and follicle scanning was also undertaken. Cervical mucus quality and sperm - cervical mucus interaction were studied on the day of onset of the LH surge. The use of clomiphene and tamoxifen resulted in a significant reduction in cervical mucus score and sperm-cervical mucus interaction as judged by the distance travelled by the vanguard spermatozoa. Cyclofenil had no effect on these parameters.

引用

页码：437 / 441

页数：5

共 22 条

[11]

LAMB JE, 1966, OBSTET GYNECOL, V28, P505

[12]

MAXSON WS, 1984, FERTIL STERIL, V42, P356

[13]

NULSEN J, 1987, FERTIL STERIL, V48, P783

[14]

PANDYA IJ, 1986, FERTIL STERIL, V45, P357

[15] UNEXPLAINED INFERTILITY - A REVIEW [J].

PEPPERELL, RJ ;

MCBAIN, JC .

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1985, 92 (06) :569-580

[16]

RANDALL JM, 1991, FERTIL STERIL, V56, P465

[17]

ROUMEN FJME, 1984, FERTIL STERIL, V41, P237

[18] COMPARISON OF EFFECTS OF CLOMIPHENE AND TAMOXIFEN TREATMENT ON CONCENTRATIONS OF ESTRADIOL AND PROGESTERONE IN PERIPHERAL PLASMA OF INFERTILE WOMEN [J].

SENIOR, BE ;

CAWOOD, ML ;

OAKEY, RE ;

MCKIDDIE, JM ;

SIDDLE, DR .

CLINICAL ENDOCRINOLOGY, 1978, 8 (05) :381-389

[19] THE EFFECT OF CLOMIPHENE CITRATE AND TAMOXIFEN ON THE CERVICAL-MUCUS [J].

TEPPER, R ;

LUNENFELD, B ;

SHALEV, J ;

OVADIA, J ;

BLANKSTEIN, J .

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1988, 67 (04) :311-314

[20]

WONG PC, 1986, FERTIL STERIL, V45, P97

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