PROHIBITIN, AN ANTIPROLIFERATIVE PROTEIN, IS LOCALIZED TO MITOCHONDRIA

被引：167

作者：

IKONEN, E ^{[1
]}

FIEDLER, K ^{[1
]}

PARTON, RG ^{[1
]}

SIMONS, K ^{[1
]}

机构：

[1] EUROPEAN MOLEC BIOL LAB,CELL BIOL PROGRAMME,D-69012 HEIDELBERG,GERMANY

来源：

FEBS LETTERS | 1995年 / 358卷 / 03期

关键词：

PROHIBITIN; MITOCHONDRIA; ANTIPROLIFERATIVE; CARCINOGENESIS;

D O I：

10.1016/0014-5793(94)01444-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prohibitin is a ubiquitously expressed protein with antiproliferative properties. When rat prohibitin tagged with a carboxy-terminal c-Myc epitope was expressed in baby hamster kidney cells the protein was targeted to mitochondria. In immunofluorescence microscopy prohibitin colocalized with a mitochondrial marker E3. Immunoelectron microscopy revealed that prohibitin was associated with the periphery of mitochondria. The amino-terminus of prohibitin shares characteristics of the known mitochondrial import signals, and positioning of the tag at the N-terminus causes accumulation of the protein in the cytoplasm. These findings help to direct functional studies on prohibitin and suggest that a mitochondrial protein may act as a tumor suppressor.

引用

页码：273 / 277

页数：5

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