DIFFERENTIAL INHIBITION OF REVERSE-TRANSCRIPTASE AND CELLULAR DNA POLYMERASE-ALPHA ACTIVITIES BY LIGNANS ISOLATED FROM CHINESE HERBS, PHYLLANTHUS-MYRTIFOLIUS MOON, AND TANNINS FROM LONICERA-JAPONICA THUNB AND CASTANOPSIS-HYSTRIX

被引:109
作者
CHANG, CW
LIN, MT
LEE, SS
LIU, KCSC
HSU, FL
LIN, JY
机构
[1] NATL TAIWAN UNIV,COLL MED,INST BIOCHEM,TAIPEI 10018,TAIWAN
[2] NATL TAIWAN UNIV,COLL MED,SCH PHARM,TAIPEI,TAIWAN
[3] TAIPEI MED COLL,SCH PHARM,TAIPEI,TAIWAN
关键词
LIGNAN; CAFFEOYLQUINATE; GALLOYLQUINATE; GALLOYLSHIKIMATE; REVERSE TRANSCRIPTASE INHIBITION;
D O I
10.1016/0166-3542(95)00020-M
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Two lignans, phyllamycin B and retrojusticidin B isolated from Phyllanthus myrtifolius Moon have been demonstrated to have a strong inhibitory effect on human immunodeficiency virus-1 reverse transcriptase activity (HIV-1 RT), but much less inhibitory effect on human DNA polymerase-alpha (HDNAP-alpha) activity. Fifty percent inhibitory concentrations of phyllamycin B and retrojusticidin B were determined to be 3.5 and 5.5 mu M for HIV-1 RT, and 289 and 989 mu M for HDNAP-alpha, respectively. The mode of inhibition was found to be non-competitive inhibition with respect to template-primer and triphosphate substrate. Several tannins such as caffeoylquinates (CQs) isolated from Lonicera japonica Thunb, galloylquinates (GQs) and galloylshikimates (GSs) purified from Castanopsis hystrix were shown to have a much less selective inhibitory effect on HIV-1 RT.
引用
收藏
页码:367 / 374
页数:8
相关论文
共 18 条
[1]   INITIAL STUDIES ON THE CELLULAR PHARMACOLOGY OF 2',3'-DIDEOXYINOSINE, AN INHIBITOR OF HIV INFECTIVITY [J].
AHLUWALIA, G ;
COONEY, DA ;
MITSUYA, H ;
FRIDLAND, A ;
FLORA, KP ;
HAO, Z ;
DALAL, M ;
BRODER, S ;
JOHNS, DG .
BIOCHEMICAL PHARMACOLOGY, 1987, 36 (22) :3797-3800
[2]   INHIBITION OF MOLONEY MURINE LEUKEMIA-VIRUS REVERSE-TRANSCRIPTASE ACTIVITY BY TETRAHYDROXYXANTHONES ISOLATED FROM THE CHINESE HERB, TRIPTEROSPERMUM-LANCEOLATUM (HYATA) [J].
CHANG, CC ;
LIN, CN ;
LIN, JY .
ANTIVIRAL RESEARCH, 1992, 19 (02) :119-127
[3]  
CHANG CW, 1994, J BIOMED SCI, V3, P163
[4]  
CHANG W, 1990, THESIS TAIPEI MED CO
[5]   INHIBITORY EFFECTS OF FLAVONOIDS ON MOLONEY MURINE LEUKEMIA-VIRUS REVERSE-TRANSCRIPTASE ACTIVITY [J].
CHU, SC ;
HSIEH, YS ;
LIN, JY .
JOURNAL OF NATURAL PRODUCTS, 1992, 55 (02) :179-183
[6]   TANNINS AND RELATED-COMPOUNDS .57. GALLIC ACID-ESTERS OF PROTO-QUERCITOL, QUINIC ACID AND (-)-SHIKIMIC ACID FROM QUERCUS-MONGOLICA AND QUERCUS-MYRSINAEFOLIA [J].
ISHIMARU, K ;
NONAKA, G ;
NISHIOKA, I .
PHYTOCHEMISTRY, 1987, 26 (05) :1501-1504
[7]  
LIN MT, 1994, IN PRESS J NAT PROD
[8]   INHIBITION OF HIV-INFECTION BY FLAVANOIDS [J].
MAHMOOD, N ;
PIZZA, C ;
AQUINO, R ;
DETOMMASI, N ;
PIACENTE, S ;
COLMAN, S ;
BURKE, A ;
HAY, AJ .
ANTIVIRAL RESEARCH, 1993, 22 (2-3) :189-199
[9]   STUDIES ON DNA ALPHA-POLYMERASE OF MOUSE MYELOMA - PARTIAL-PURIFICATION AND COMPARISON OF 3 MOLECULAR-FORMS OF ENZYME [J].
MATSUKAGE, A ;
SIVARAJAN, M ;
WILSON, SH .
BIOCHEMISTRY, 1976, 15 (24) :5305-5314
[10]   DEXTRAN SULFATE SUPPRESSION OF VIRUSES IN THE HIV FAMILY - INHIBITION OF VIRION BINDING TO CD4+ CELLS [J].
MITSUYA, H ;
LOONEY, DJ ;
KUNO, S ;
UENO, R ;
WONGSTAAL, F ;
BRODER, S .
SCIENCE, 1988, 240 (4852) :646-649