CANCELLOUS BONE-RESORPTION IN THE PROXIMAL ILIUM OF THE OVARIECTOMIZED RAT

被引:21
作者
DEVLIN, H
FERGUSON, MWJ
CARTER, DH
机构
[1] UNIV MANCHESTER, DEPT CELL & STRUCT BIOL, MANCHESTER M13 9PL, LANCS, ENGLAND
[2] UNIV MANCHESTER, DENT HOSP, DEPT ORAL MED, MANCHESTER M15 6FH, LANCS, ENGLAND
关键词
Bone resorption; Histomorphometry; Ovariectomy; Rat;
D O I
10.1007/BF02554970
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Bone histomorphometry was performed on the proximal ilium of mature Sprague-Dawley rats following ovariectomy, and these rats were compared with sham-operated controls. Bone volume per unit tissue volume (BV/TV), osteoid surface, and the depth and extent of eroded cavities were measured in animals killed at intervals after operation. The rate of bone loss and the mean osteoid surface in the proximal ilium of the ovariectomized rats was significantly greater than that of the control rats over a 210-day postoperative period. The eroded surface and mean trabecular thickness in the proximal ilium of the ovariectomized rats were not significantly different from that of the control rats, and therefore failed to explain the difference in the rate of bone loss. The distribution of the depths of trabecular eroded cavities in the ilium of ovariectomized rats was different from that in the control rats. The loss of trabecular bone mass in the proximal ilium of ovariectomized, mature rats appeared due to increased activity of individual osteoclasts, rather than to increased osteoclast numbers and thinning of trabeculae. © 1990 Springer-Verlag New York Inc.
引用
收藏
页码:395 / 400
页数:6
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