PROTEIN-KINASE-C SUBSPECIES IN ESTROGEN RECEPTOR-POSITIVE AND RECEPTOR-NEGATIVE HUMAN BREAST-CANCER CELL-LINES

被引：29

作者：

BIGNON, E ^{[1
]}

OGITA, K ^{[1
]}

KISHIMOTO, A ^{[1
]}

NISHIZUKA, Y ^{[1
]}

机构：

[1] KOBE UNIV,BIOSIGNAL RES CTR,KOBE 657,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)90793-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Estrogen receptor-positive (MCF7) and -negative (BT20) human breast cancer cell lines, which are frequently used for studies on cancer chemotherapy with triphenylethylene (TPE) anti-estrogens, express at least three protein kinase C subspecies. Two of them are identified as type II PKC having the β-sequence and type III PKC having the α-sequence. The other one shows typical characteristics of PKC which responds to Ca2+, phosphatidyl-serine and diacylglycerol, but shows kinetic properties subtly different from the previously known PKC subspecies. Immunoblot analysis has shown that this enzyme does not correspond to any of the well defined subspecies with known sequence structures. All of these PKC subspecies are similarly susceptible to the TPE antiestrogens. © 1990.

引用

页码：1071 / 1078

页数：8

共 22 条

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