FURTHER NEUROENDOCRINE EVIDENCE FOR REDUCED D(2)-DOPAMINE RECEPTOR FUNCTION IN ALCOHOLISM

被引：54

作者：

BALLDIN, J

BERGGREN, U

LINDSTEDT, G

SUNDKLER, A

机构：

[1] GOTHENBURG UNIV,DEPT PSYCHIAT & NEUROCHEM,S-41124 GOTHENBURG,SWEDEN

[2] GOTHENBURG UNIV,DEPT CLIN CHEM,S-41124 GOTHENBURG,SWEDEN

来源：

DRUG AND ALCOHOL DEPENDENCE | 1993年 / 32卷 / 02期

关键词：

LONG-TERM ABSTINENT ALCOHOLICS; DOPAMINE RECEPTOR FUNCTION;

D O I：

10.1016/0376-8716(93)80008-3

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

D2 dopamine receptor function, as assessed by growth hormone (GH) responses to apomorphine (APO; 0.18-0.24 mg i.v.), was investigated in 15 male alcoholics with reported long-term abstinence. Results from only nine subjects could be evaluated. These subjects had been heavy alcohol consumers for a mean of 15 +/- 10 years and had thereafter been abstinent for a mean of 7 +/- 6 years prior to the investigation. Eight male healthy subjects, all of whom were light social drinkers, were selected as controls. The maximum GH responses to APO were significantly lower in the alcoholics (5.8 +/- 5.8 mU/l) than in the controls (22.1 +/- 19.2 mU/l). This finding gives neuroendocrine evidence for reduced D2 dopamine receptor function in alcoholics with long-term abstinence.

引用

页码：159 / 162

页数：4