SPECIFIC MESSENGER-RNAS ACCUMULATE IN LONG-WAVELENGTH UV-IRRADIATED MOUSE EPIDERMIS

被引：10

作者：

BRUNET, S

GIACOMONI, PU

机构：

[1] Department of Biology, Laboratoire de Recherche Fondamentale de l'Oréal

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1990年 / 6卷 / 04期

关键词：

Gene expression; oncogenes; UV light;

D O I：

10.1016/1011-1344(90)85116-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Total RNA from hairless mice epidermis was analysed by RNA-DNA hybridization on slot blots at various times following irradiation with long-wavelength UV light (UV-B or UV-B plus UV-A). Densitometric scanning of the autoradiographies indicates that the amount of RNA which hybridizes with an Ha-ras DNA probe remains constant for up to 72 h after irradiation. The amount of the transcript which hybridizes to a c-fos DNA probe increases dose dependently from 15 min to 2 h after irradiation. RNA which hybridizes to a tubulin DNA probe accumulates in parallel with the increase in mitotic index associated with the radiation-induced hyperplasia. © 1990.

引用

页码：431 / 441

页数：11

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