AN ACTION SPECTRUM FOR THE ELICITATION OF ERYTHEMA IN SKIN PERSISTENTLY SENSITIZED BY PHOTOBOUND 8-METHOXYPSORALEN

被引：39

作者：

ORTEL, B ^{[1
]}

GANGE, RW ^{[1
]}

机构：

[1] HARVARD UNIV, MASSACHUSETTS GEN HOSP,SCH MED, DEPT DERMATOL PHOTOMED,WELLMAN LABS, BOSTON, MA 02114 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1990年 / 94卷 / 06期

关键词：

D O I：

10.1111/1523-1747.ep12874639

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Human skin can be rendered persistently photosensitive by topical application of aqueous 8-methoxypsoralen (8-MOP) and exposure to a suberythemogenic dose of more than 380 rim radiation. We report an action spectrum for the elicitation of phototoxic erythema induced by a second exposure of skin pretreated in this way. After correction for unsensitized skin erythema this action spectrum resembles the absorption spectrum of the 4′,5′-monoadduct of 8-MOP to DNA. This suggests that the monoadduct is the chromophore for erythema elicited by the second irradiation, and supports the DNA crosslink as the crucial photoproduct causing phototoxic erythema due to 8-MOP in human skin. © 1990.

引用

页码：781 / 785

页数：5

共 29 条

[1] EFFECT OF CUTANEOUS HYPOXIA UPON ERYTHEMA AND PIGMENT RESPONSES TO UVA, UVB, AND PUVA (8-MOP+UVA) IN HUMAN-SKIN [J].

AULETTA, M ;

GANGE, RW ;

TAN, OT ;

MATZINGER, E .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1986, 86 (06) :649-652

[2] MUTAGENIC AND RECOMBINOGENIC ACTION OF DNA MONOADDUCTS PHOTOINDUCED BY THE BIFUNCTIONAL FUROCOUMARIN 8-METHOXYPSORALEN IN YEAST (SACCHAROMYCES-CEREVISIAE) [J].

AVERBECK, D ;

AVERBECK, S ;

CUNDARI, E .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1987, 45 (03) :371-379

[3] RELATIONSHIP BETWEEN LESIONS PHOTOINDUCED BY MONO-FUNCTIONAL AND BI-FUNCTIONAL FUROCOUMARINS IN DNA AND GENOTOXIC EFFECTS IN DIPLOID YEAST [J].

AVERBECK, D .

MUTATION RESEARCH, 1985, 151 (02) :217-233

[4] AN ACTION SPECTRUM FOR LETHAL PHOTOSENSITIZATION OF CANDIDA-ALBICANS BY 8-MOP AFTER LOW-DOSE BROAD-BAND UV-A IRRADIATION - AN ACTION SPECTRUM FOR 8-MOP 4',5'-MONOADDUCTS [J].

BAYDOUN, SA ;

YOUNG, AR .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1987, 46 (02) :311-314

[5] SPECTROSCOPIC PROPERTIES AND PHOTOREACTIVITY WITH DNA OF NEW MONOFUNCTIONAL PYRIDOPSORALENS [J].

BLAIS, J ;

VIGNY, P ;

MORON, J ;

BISAGNI, E .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1984, 39 (02) :145-150

[6] PSORALEN ADDUCTS IN A SHUTTLE VECTOR PLASMID PROPAGATED IN PRIMATE CELLS - HIGH MUTAGENICITY OF DNA CROSS-LINKS [J].

BREDBERG, A ;

NACHMANSSON, N .

CARCINOGENESIS, 1987, 8 (12) :1923-1927

[7] TRANSMISSION OF HUMAN-EPIDERMIS AND STRATUM-CORNEUM AS A FUNCTION OF THICKNESS IN THE ULTRAVIOLET AND VISIBLE WAVELENGTHS [J].

BRULS, WAG ;

SLAPER, H ;

VANDERLEUN, JC ;

BERRENS, L .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1984, 40 (04) :485-494

[8] REPAIR OF 8-METHOXYPSORALEN PHOTOINDUCED CROSS-LINKS AND MUTAGENESIS - ROLE OF THE DIFFERENT REPAIR PATHWAYS IN YEAST [J].

CASSIER, C ;

CHANET, R ;

MOUSTACCHI, E .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1985, 41 (03) :289-294

[9] PHOTO-CHEMICAL PRODUCTION OF PSORALEN - DNA MONOADDUCTS CAPABLE OF SUBSEQUENT PHOTOCROSSLINKING [J].

CHATTERJEE, PK ;

CANTOR, CR .

NUCLEIC ACIDS RESEARCH, 1978, 5 (10) :3619-3633

[10] ACTION SPECTRA OF TOPICAL PSORALENS - A RE-EVALUATION [J].

CRIPPS, DJ ;

LOWE, NJ ;

LERNER, AB .

BRITISH JOURNAL OF DERMATOLOGY, 1982, 107 (01) :77-82

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