AN ACTION SPECTRUM FOR THE ELICITATION OF ERYTHEMA IN SKIN PERSISTENTLY SENSITIZED BY PHOTOBOUND 8-METHOXYPSORALEN

被引：39

作者：

ORTEL, B ^{[1
]}

GANGE, RW ^{[1
]}

机构：

[1] HARVARD UNIV, MASSACHUSETTS GEN HOSP,SCH MED, DEPT DERMATOL PHOTOMED,WELLMAN LABS, BOSTON, MA 02114 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1990年 / 94卷 / 06期

关键词：

D O I：

10.1111/1523-1747.ep12874639

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Human skin can be rendered persistently photosensitive by topical application of aqueous 8-methoxypsoralen (8-MOP) and exposure to a suberythemogenic dose of more than 380 rim radiation. We report an action spectrum for the elicitation of phototoxic erythema induced by a second exposure of skin pretreated in this way. After correction for unsensitized skin erythema this action spectrum resembles the absorption spectrum of the 4′,5′-monoadduct of 8-MOP to DNA. This suggests that the monoadduct is the chromophore for erythema elicited by the second irradiation, and supports the DNA crosslink as the crucial photoproduct causing phototoxic erythema due to 8-MOP in human skin. © 1990.

引用

页码：781 / 785

页数：5

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