POSTISCHEMIC ALTERATION OF [H-3] FORSKOLIN BINDING-SITES IN SELECTIVELY VULNERABLE AREAS - AN AUTORADIOGRAPHIC STUDY OF GERBIL BRAIN

被引：18

作者：

ARAKI, T ^{[1
]}

KATO, H ^{[1
]}

HARA, H ^{[1
]}

KOGURE, K ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,INST BRAIN DIS,DEPT NEUROL,SENDAI,MIYAGI 980,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 125卷 / 02期

关键词：

FORSKOLIN; AUTORADIOGRAPHY; CEREBRAL ISCHEMIA; SELECTIVE VULNERABILITY; GERBIL;

D O I：

10.1016/0304-3940(91)90016-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The postischemic alteration in forskolin receptor binding sites 1 h to 1 month after transient cerebral ischemia was studied in the gerbil. Forskolin binding showed marked reduction in the striatum at an early stage of recirculation, whereas a transient increase was seen in the frontal cortex, the hippocampal regions, and the thalamus. The dentate molecular layer and the parietal cortex revealed no significant changes in the forskolin receptor binding. However, a significant reduction in the forskolin receptor binding was found in these areas after 48 h or 7 days of recirculation. These results suggest that the neuronal damage in the selectively vulnerable areas following transient cerebral ischemia may process with different mechanisms.

引用

页码：159 / 162

页数：4