MONO-AMINE NEURON REGULATION OF LRF NEURONS INNERVATING THE ORGANUM VASCULOSUM LAMINAE TERMINALIS AND MEDIAN-EMINENCE

The LRF content of the median eminence (ME) and organum vasculosum laminae terminalis (OVLT) was analyzed following lesions destroying the serotonin neurons of the midbrain raphe and the dopamine neurons of the zona incerta. Six weeks after zona incerta lesions the LFT content of both OVLT and ME was significantly reduced. Raphe lesions did not significantly reduce LRF content of the ME or OVLT. No changes in circulating LH content were noted after either lesion. These observations suggest that the dopamine neurons of the incerto-hypothalamic system may be involved in the regulation of LRF synthesis or release from LRF neurons innervating the ME and OVLT. © 1979.