BIOLOGIC CHARACTERISTICS OF SPECIFIC HUMAN PAPILLOMAVIRUS TYPES PREDICTED FROM MORPHOLOGY OF CERVICAL LESIONS

被引:38
作者
KADISH, AS
HAGAN, RJ
RITTER, DB
GOLDBERG, GL
ROMNEY, SL
KANETSKY, PA
BEISS, BK
BURK, RD
机构
[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT OBSTET & GYNECOL,BRONX,NY 10461
[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PEDIAT,BRONX,NY 10461
[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL,BRONX,NY 10461
关键词
HUMAN PAPILLOMAVIRUS; CERVICAL INTRAEPITHELIAL NEOPLASIA; ONCOLOGIC POTENTIAL; SOUTHERN BLOT HYBRIDIZATION; PAPANICOLAOU SMEAR; BETHESDA SYSTEM; IMMUNOHISTOCHEMISTRY; L1 MAJOR CAPSID ANTIGEN; SQUAMOUS INTRAEPITHELIAL LESION;
D O I
10.1016/0046-8177(92)90294-D
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Human papillomavirus (HPV) DNA was detected by Southern blot hybridization in cervicovaginal lavage samples from 199 of 329 (60.5%) women attending a municipal hospital colposcopy clinic. Human papillomavirus was identified in 195 of 264 (73.9%) patients with a squamous intraepithelial lesion or cancer on biopsy or Papanicolaou smear (Bethesda system) compared with 11 of 65 (16.9%) without squamous intraepithelial lesion (P < .0001). The most common HPV type identified was HPV 16 (20.6% of positive samples), and 36.7% of isolates contained uncharacterized HPVs. Of women with cervical intraepithelial neoplasia (CIN) grade III or cancer, 23.4% were infected with HPV 16 compared with less than 4% with any other single HPV type. Based on biopsy diagnosis in patients infected with specific HPV types, HPVs 6 and 11 had low oncogenic potential; HPVs 18, 31, 35, and 45 had intermediate oncogenic potential; and HPVs 16 and 33 had high oncogenic potential. Hyperchromatic, unusually enlarged nuclei ("meganuclei"), and/or abnormal mitoses were found significantly more often in lesions infected with HPVs 16, 33, and 35 than in those infected with HPVs 6, 11, 18, 31, and 45, even in low-grade lesions, and may represent a histologic marker for HPVs with significant oncogenic potential. Human papillomavirus capsid protein was detected significantly less often by immunocytochemical staining in CIN I and CIN II lesions infected with HPVs 16 and 33 (8.3%) than in those infected with HPVs 6, 11, 18, and 31 (60%; P = .007), suggesting early abnormalities in cellular differentiation in lesions infected with highly oncogenic HPVs. © 1992.
引用
收藏
页码:1262 / 1269
页数:8
相关论文
共 33 条
  • [1] [Anonymous], 1990, HUM PATHOL, V21, P704
  • [2] PAPILLOMAVIRUSES AND HUMAN CANCER
    ARENDS, MJ
    WYLLIE, AH
    BIRD, CC
    [J]. HUMAN PATHOLOGY, 1990, 21 (07) : 686 - 698
  • [3] POSSIBLE PROGNOSTIC-SIGNIFICANCE OF HUMAN PAPILLOMAVIRUS TYPE IN CERVICAL-CANCER
    BARNES, W
    DELGADO, G
    KURMAN, RJ
    PETRILLI, ES
    SMITH, DM
    AHMED, S
    LORINCZ, AT
    TEMPLE, GF
    JENSON, AB
    LANCASTER, WD
    [J]. GYNECOLOGIC ONCOLOGY, 1988, 29 (03) : 267 - 273
  • [4] BERGERON C, 1987, OBSTET GYNECOL, V69, P736
  • [5] CLINICAL AND HISTOLOGIC FEATURES OF VULVAR CARCINOMAS ANALYZED FOR HUMAN PAPILLOMAVIRUS STATUS - EVIDENCE THAT SQUAMOUS-CELL CARCINOMA OF THE VULVA HAS MORE THAN ONE ETIOLOGY
    BLOSS, JD
    LIAO, SY
    WILCZYNSKI, SP
    MACRI, C
    WALKER, J
    PEAKE, M
    BERMAN, ML
    [J]. HUMAN PATHOLOGY, 1991, 22 (07) : 711 - 718
  • [6] A NEW TYPE OF PAPILLOMAVIRUS DNA, ITS PRESENCE IN GENITAL CANCER BIOPSIES AND IN CELL-LINES DERIVED FROM CERVICAL-CANCER
    BOSHART, M
    GISSMANN, L
    IKENBERG, H
    KLEINHEINZ, A
    SCHEURLEN, W
    HAUSEN, HZ
    [J]. EMBO JOURNAL, 1984, 3 (05) : 1151 - 1157
  • [7] HUMAN PAPILLOMAVIRUS INFECTION OF THE CERVIX DETECTED BY CERVICOVAGINAL LAVAGE AND MOLECULAR HYBRIDIZATION - CORRELATION WITH BIOPSY RESULTS AND PAPANICOLAOU SMEAR
    BURK, RD
    KADISH, AS
    CALDERIN, S
    ROMNEY, SL
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1986, 154 (05) : 982 - 989
  • [8] CAMPION MJ, 1986, LANCET, V2, P237
  • [9] CERVICAL PAPILLOMAVIRUSES SEGREGATE WITHIN MORPHOLOGICALLY DISTINCT PRECANCEROUS LESIONS
    CRUM, CP
    MITAO, M
    LEVINE, RU
    SILVERSTEIN, S
    [J]. JOURNAL OF VIROLOGY, 1985, 54 (03) : 675 - 681
  • [10] HUMAN PAPILLOMAVIRUS TYPE-16 AND EARLY CERVICAL NEOPLASIA
    CRUM, CP
    IKENBERG, H
    RICHART, RM
    GISSMANN, L
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (14) : 880 - 883