IN-VITRO PROTON MAGNETIC-RESONANCE SPECTROSCOPY OF 4 HUMAN PROSTATE-CANCER CELL-LINES

被引：19

作者：

CORNEL, EB

SMITS, GAHJ

DERUIJTER, JE

OOSTERHOF, GON

HEERSCHAP, A

DEBRUYNE, FMJ

SCHALKEN, JA

机构：

[1] UNIV NIJMEGEN HOSP, DEPT UROL, 6500 HB NIJMEGEN, NETHERLANDS

[2] UNIV NIJMEGEN HOSP, DEPT RADIOL, 6500 HB NIJMEGEN, NETHERLANDS

来源：

PROSTATE | 1995年 / 26卷 / 05期

关键词：

H-1; MRS; HUMAN PROSTATE CANCER LINES; METABOLISM; PROSTATE CANCER;

D O I：

10.1002/pros.2990260508

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is accumulating evidence that some biochemical pathways observable by magnetic resonance spectroscopy, e.g., citrate acid and phospholipid metabolism, are altered in human prostate cancer. Four well-established human prostate cancer cell lines were therefore studied with magnetic resonance spectroscopy to compare differences in metabolic content with tumor biological behavior. Herein we demonstrate that, although each cell line has its own metabolic profile, relative creatine and citrate levels can be used to discriminate the androgen-dependent LNCaP cell line from the androgen-independent DU-145, TSU, and PC-3 cell lines. (C) 1995 Wiley-Liss, Inc.

引用

页码：275 / 280

页数：6

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