CONTRIBUTION OF GLIAL-CELLS TO HISTAMINE INACTIVATION

被引：14

作者：

HUSZTI, Z ^{[1
]}

MAGYAR, K ^{[1
]}

KALMAN, M ^{[1
]}

机构：

[1] SEMMELWEIS UNIV MED,DEPT ANAT 1,H-1445 BUDAPEST,HUNGARY

来源：

AGENTS AND ACTIONS | 1990年 / 30卷 / 1-2期

关键词：

D O I：

10.1007/BF01969048

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

dl-α-aminoadipic acid (dl-αAA), a selective gliotoxic agent produced significant reductions in histamine-N-methyl-transferase (HNMT) and monoamine oxidase-B (MAO-B) activities and an enhancement in histamine (HA) level in the hypothalamus of rats 2 and 4 h after single intracerebroventricular (i.c.v.) or subcutaneous (s.c.) injections of the compound. Histidine decarboxylase (HD) and monoamine oxidase-A (MAO-A) were unaffected after these treatments. Following a single i.c.v. injection of dl-αAA of 200 μg/rat, or a single s.c. injection of 5 mg/rat, marked diminutions in the astrocytic marker glutamine synthetase (GS) activity occured suggesting marked glial damage in the hypothalamus. In total, these studies indicate an important role for glial cells in HA metabolism (inactivation). © 1990 Birkhäuser Verlag.

引用

页码：237 / 239

页数：3

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